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Table 3 Baseline Person-Based Characteristics Associated with Accelerated Knee Osteoarthritis (AKOA) During Each Phase

From: The incidence and characteristics of accelerated knee osteoarthritis among women: the Chingford cohort

Phase 1: Year 1 - Year 5 (n = 715; 702 in model)
VariableNo KOA (n = 585)Typical KOA (n = 92)AKOA (n = 25)AKOA vs No KOAAKOA vs Typical KOAAKOA vs No KOAAKOA vs Typical KOA
m (sd)m (sd)m (sd)OR (95% CI)OR (95% CI)aOR (95% CI)aOR (95% CI)
Age (sd = 5.8 years)53.7 (5.9)55.6 (5.3)56.7 (5.0)1.65 (1.10, 2.47)1.20 (0.77, 1.87)1.88 (1.21, 2.93)1.29 (0.79, 2.10)
BMI (sd = 3.9 kg/m2)24.9 (3.7)26.4 (4.6)25.9 (3.8)1.30 (0.90, 1.87)0.91 (0.61, 1.34)1.30 (0.87, 1.93)0.87 (0.57, 1.34)
Systolic BP (sd = 20 mmHg)127 (21)128 (19)126 (15)0.95 (0.63, 1.44)0.90 (0.58, 1.42)0.44 (0.21, 0.91)0.53 (0.24, 1.16)
Diastolic BP (sd = 11 mmHg)78 (11)79 (11)80 (8)1.22 (0.84, 1.77)1.13 (0.74, 1.71)1.75 (0.91, 3.36)1.78 (0.87, 3.62)
Phase 2: Year 5 - Year 10 (n = 574; 539 used in model)
VariableNo KOA (n = 365)Typical KOA (n = 157)AKOA (n = 17)AKOA vs No KOAAKOA vs Typical KOAAKOA vs No KOAAKOA vs Typical KOA
m (sd)m (sd)m (sd)OR (95% CI)OR (95% CI)aOR (95% CI)aOR (95% CI)
Age (sd = 5.8 years)57.2 (5.6)58.1 (5.8)62.1 (6.5)2.33 (1.39, 3.90)1.98 (1.17, 3.35)2.87 (1.61, 5.11)2.54 (1.41, 4.56)
BMI (sd = 4.1 kg/m2)25.5 (3.8)26.4 (4.6)29.1 (4.6)1.96 (1.35, 2.86)1.55 (1.06, 2.26)2.76 (1.69, 4.52)2.26 (1.37, 3.71)
Systolic BP (sd = 19 mmHg)123 (19)127 (20)125 (16)1.09 (0.67, 1.77)0.89 (0.54, 1.46)0.89 (0.47, 1.68)0.81 (0.42, 1.54)
Diastolic BP (sd = 12 mmHg)74 (12)75.6 (13)69.4 (15)0.66 (0.38, 1.14)0.56 (0.32, 0.99)0.39 (0.20, 0.75)0.38 (0.20, 0.74)
Phase 3: Year 10 - Year 15 (n = 377; 374 used in model)
VariableNo KOA (n = 272)Typical KOA (n = 82)AKOA (n = 20)AKOA vs No KOAAKOA vs Typical KOAAKOA vs No KOAAKOA vs Typical KOA
m (sd)m (sd)m (sd)OR (95% CI)OR (95% CI)aOR (95% CI)aOR (95% CI)
Age (sd = 5.5 years)61.4 (5.5)61.1 (5.1)63.9 (6.4)1.52 (0.98, 2.35)1.62 (1.01, 2.60)1.38 (0.88, 2.15)1.35 (0.83, 2.22)
BMI (sd = 3.9 kg/m2)25.5 (3.7)26.7 (4.4)26.1 (3.8)1.17 (0.75, 1.83)0.87 (0.54, 1.40)1.08 (0.67, 1.74)0.78 (0.47, 1.31)
Systolic BP (sd = 21 mmHg)135 (23)131 (15)146 (24)1.47 (1.02, 2.12)1.87 (1.22, 2.89)1.32 (0.78, 2.27)2.13 (1.14, 4.01)
Diastolic BP (sd = 11 mmHg)80 (11)81 (10)84 (13)1.36 (0.89, 2.10)1.33 (0.83, 2.11)1.05 (0.57, 1.91)0.82 (0.43, 1.58)
Meta-Analysis of Baseline Characteristics from the 3 Phases
VariableAKOA vs No KOAAKOA vs Typical KOAAKOA vs No KOAAKOA vs Typical KOA
OR (95% CI)OR (95% CI)aOR (95% CI)aOR (95% CI)
Age (sd = 5.8 years)1.75 (1.35 to 2.26)1.52 (1.16 to 2.01)1.84 (1.40 to 2.43)1.56 (1.16 to 2.11)
BMI (sd = 3.9 kg/m2)1.47 (1.17 to 1.84)1.11 (0.87 to 1.40)1.52 (1.17 to 1.97)1.13 (0.86 to 1.48)
Systolic BP (sd = 20 mmHg)1.18 (0.93 to 1.50)1.18 (0.91 to 1.53)0.90 (0.63 to 1.28)1.06 (0.72 to 1.57)
Diastolic BP (sd = 11 mmHg)1.11 (0.87 to 1.43)1.01 (0.77 to 1.33)0.91 (0.63 to 1.31)0.79 (0.53 to 1.16)
  1. KOA knee osteoarthritis, m mean, sd standard deviation, OR odds ratio (per 1 standard deviation), 95% CI 95% confidence interval, aOR adjusted odds ratio (adjusted for other variables in table), BMI body mass index, BP blood pressure
  2. All boldface entries are statistically significant (p < 0.05) with confidence intervals that don't include 1.00