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Table 3 Baseline Person-Based Characteristics Associated with Accelerated Knee Osteoarthritis (AKOA) During Each Phase

From: The incidence and characteristics of accelerated knee osteoarthritis among women: the Chingford cohort

Phase 1: Year 1 - Year 5 (n = 715; 702 in model)

Variable

No KOA (n = 585)

Typical KOA (n = 92)

AKOA (n = 25)

AKOA vs No KOA

AKOA vs Typical KOA

AKOA vs No KOA

AKOA vs Typical KOA

m (sd)

m (sd)

m (sd)

OR (95% CI)

OR (95% CI)

aOR (95% CI)

aOR (95% CI)

Age (sd = 5.8 years)

53.7 (5.9)

55.6 (5.3)

56.7 (5.0)

1.65 (1.10, 2.47)

1.20 (0.77, 1.87)

1.88 (1.21, 2.93)

1.29 (0.79, 2.10)

BMI (sd = 3.9 kg/m2)

24.9 (3.7)

26.4 (4.6)

25.9 (3.8)

1.30 (0.90, 1.87)

0.91 (0.61, 1.34)

1.30 (0.87, 1.93)

0.87 (0.57, 1.34)

Systolic BP (sd = 20 mmHg)

127 (21)

128 (19)

126 (15)

0.95 (0.63, 1.44)

0.90 (0.58, 1.42)

0.44 (0.21, 0.91)

0.53 (0.24, 1.16)

Diastolic BP (sd = 11 mmHg)

78 (11)

79 (11)

80 (8)

1.22 (0.84, 1.77)

1.13 (0.74, 1.71)

1.75 (0.91, 3.36)

1.78 (0.87, 3.62)

Phase 2: Year 5 - Year 10 (n = 574; 539 used in model)

Variable

No KOA (n = 365)

Typical KOA (n = 157)

AKOA (n = 17)

AKOA vs No KOA

AKOA vs Typical KOA

AKOA vs No KOA

AKOA vs Typical KOA

m (sd)

m (sd)

m (sd)

OR (95% CI)

OR (95% CI)

aOR (95% CI)

aOR (95% CI)

Age (sd = 5.8 years)

57.2 (5.6)

58.1 (5.8)

62.1 (6.5)

2.33 (1.39, 3.90)

1.98 (1.17, 3.35)

2.87 (1.61, 5.11)

2.54 (1.41, 4.56)

BMI (sd = 4.1 kg/m2)

25.5 (3.8)

26.4 (4.6)

29.1 (4.6)

1.96 (1.35, 2.86)

1.55 (1.06, 2.26)

2.76 (1.69, 4.52)

2.26 (1.37, 3.71)

Systolic BP (sd = 19 mmHg)

123 (19)

127 (20)

125 (16)

1.09 (0.67, 1.77)

0.89 (0.54, 1.46)

0.89 (0.47, 1.68)

0.81 (0.42, 1.54)

Diastolic BP (sd = 12 mmHg)

74 (12)

75.6 (13)

69.4 (15)

0.66 (0.38, 1.14)

0.56 (0.32, 0.99)

0.39 (0.20, 0.75)

0.38 (0.20, 0.74)

Phase 3: Year 10 - Year 15 (n = 377; 374 used in model)

Variable

No KOA (n = 272)

Typical KOA (n = 82)

AKOA (n = 20)

AKOA vs No KOA

AKOA vs Typical KOA

AKOA vs No KOA

AKOA vs Typical KOA

m (sd)

m (sd)

m (sd)

OR (95% CI)

OR (95% CI)

aOR (95% CI)

aOR (95% CI)

Age (sd = 5.5 years)

61.4 (5.5)

61.1 (5.1)

63.9 (6.4)

1.52 (0.98, 2.35)

1.62 (1.01, 2.60)

1.38 (0.88, 2.15)

1.35 (0.83, 2.22)

BMI (sd = 3.9 kg/m2)

25.5 (3.7)

26.7 (4.4)

26.1 (3.8)

1.17 (0.75, 1.83)

0.87 (0.54, 1.40)

1.08 (0.67, 1.74)

0.78 (0.47, 1.31)

Systolic BP (sd = 21 mmHg)

135 (23)

131 (15)

146 (24)

1.47 (1.02, 2.12)

1.87 (1.22, 2.89)

1.32 (0.78, 2.27)

2.13 (1.14, 4.01)

Diastolic BP (sd = 11 mmHg)

80 (11)

81 (10)

84 (13)

1.36 (0.89, 2.10)

1.33 (0.83, 2.11)

1.05 (0.57, 1.91)

0.82 (0.43, 1.58)

Meta-Analysis of Baseline Characteristics from the 3 Phases

Variable

AKOA vs No KOA

AKOA vs Typical KOA

AKOA vs No KOA

AKOA vs Typical KOA

OR (95% CI)

OR (95% CI)

aOR (95% CI)

aOR (95% CI)

Age (sd = 5.8 years)

1.75 (1.35 to 2.26)

1.52 (1.16 to 2.01)

1.84 (1.40 to 2.43)

1.56 (1.16 to 2.11)

BMI (sd = 3.9 kg/m2)

1.47 (1.17 to 1.84)

1.11 (0.87 to 1.40)

1.52 (1.17 to 1.97)

1.13 (0.86 to 1.48)

Systolic BP (sd = 20 mmHg)

1.18 (0.93 to 1.50)

1.18 (0.91 to 1.53)

0.90 (0.63 to 1.28)

1.06 (0.72 to 1.57)

Diastolic BP (sd = 11 mmHg)

1.11 (0.87 to 1.43)

1.01 (0.77 to 1.33)

0.91 (0.63 to 1.31)

0.79 (0.53 to 1.16)

  1. KOA knee osteoarthritis, m mean, sd standard deviation, OR odds ratio (per 1 standard deviation), 95% CI 95% confidence interval, aOR adjusted odds ratio (adjusted for other variables in table), BMI body mass index, BP blood pressure
  2. All boldface entries are statistically significant (p < 0.05) with confidence intervals that don't include 1.00