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Fig. 4 | BMC Musculoskeletal Disorders

Fig. 4

From: M1 macrophage infiltration exacerbate muscle/bone atrophy after peripheral nerve injury

Fig. 4

Dexamethasone, pregabalin, and loxoprofen suppress M1 macrophage infiltration and muscle/bone atrophy after nerve injury. We used a chronic constriction injury (CCI) model mouse model as a nerve injury model. a Osteoclast numbers were significantly lower as per immunohistochemical analysis of the femoral bone in drug administration groups (n = 8, *P < 0.05). Center lines of box plot indicate median, box limits indicate the 25th and 75th percentiles, and whiskers extend to minimum and maximum values. b The biceps femoris muscles 1 week after CCI showed that M1 macrophage numbers were significantly lower as per flow cytometry in the drug administration groups. In the gastrocnemius muscles 1 week after CCI, M1 macrophage numbers were significantly lower in the drug administration groups. (n = 8, *P < 0.05). c The weights of biceps femoris muscles 1 week after CCI were significantly higher in the drug administration groups. According to multiple comparisons to the untreated group, muscle weights were significantly higher in the dexamethasone, pregabalin, and loxoprofen groups. In the gastrocnemius muscles 1 week after CCI, muscle weights were significantly higher in the drug administration groups (n = 8, *P < 0.05). d Regarding the femur, there were no significant differences in total bone density in the dexamethasone group at 3 weeks after administration. Total bone density significantly decreased in the pregabalin and loxoprofen groups. Regarding the tibia, there were no significant differences in total bone density in all groups at 3 weeks after administration (n = 8, * P < 0.05). Dot plots indicate median and error bars indicate the 25th and 75th percentiles

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