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Table 4 The incidence of TTR and immunoglobulin light-chain amyloid from tissue samples removed during common orthopedic operations

From: Musculoskeletal pathology as an early warning sign of systemic amyloidosis: a systematic review of amyloid deposition and orthopedic surgery

  Total Patients Male/Female (when specified) Patients with Orthopedic Biopsy TTR + Biopsy Ig Light-Chain + Biopsy % of patients with TTR or light-chain+ Biopsy
All Studies 3606 1625/1956 2183 410 8 19.1%
CTS with Biopsy 1753 520/1071 1753 241 7 14.1%
LSS with Biopsya 157 81/40 157 64 0 40.8%
Hip and Knee OA with Biopsy 382 82/294 382 97 1 25.7%
  1. CTS carpal tunnel syndrome, Ig immunoglobulin, LSS lumbar spinal stenosis, % percentage, + positive, OA osteoarthritis
  2. aExcludes Gies et al. study due to the authors not differentiating lumbar spinal stenosis patients from lumbar disc herniation patients