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Table 4 The association between depression severity at baseline and change in joint symptom over 24 months (N = 337)

From: Depression in patients with knee osteoarthritis: risk factors and associations with joint symptoms

  Univariable
β (95% CI)
Multivariable
β (95% CI)
WOMAC score
 Pain (0–500) a
  No depression Reference Reference
  Mild depression −35.8 (−63.7, −7.9) −12.4 (−36.7, 11.8)
  Moderate to severe depression −100.3 (− 143.1, −57.4) −32.0 (−72.2, 8.2)
 Function (0–1700) b
  No depression Reference Reference
  Mild depression − 139.9 (− 222.2, − 57.7) −67.8 (− 145.4, 9.7)
  Moderate to severe depression − 225.4 (− 357.5, −93.2) −90.3 (−220.3, 39.7)
 Stiffness (0–200) c
  No depression Reference Reference
  Mild depression −13.2 (−26.0, −0.5) −5.2 (−16.5, 6.1)
  Moderate to severe depression −29.4 (−49.0, − 9.8) −11.8 (−30.0, 6.5)
  1. a Multivariable analysis was adjusted for age, sex, BMI, baseline 25-(OH)D level, treatment arm and baseline WOMAC pain score
  2. b Multivariable analysis was adjusted for age, sex, BMI, baseline 25-(OH)D level, treatment arm and baseline WOMAC function score
  3. c Multivariable analysis was adjusted for age, sex, BMI, baseline 25-(OH)D level, treatment arm and baseline WOMAC stiffness score