Herpes zoster in patients with sciatica

Table 3 Incidence of herpes zoster by age, sex and comorbidity and Cox model measured hazards ratio for patients with Sciatica compared those without Sciatica

Variables	Sciatica						Crude HR (95% CI)	Adjusted HR^b (95% CI)
	No			Yes
	Event	PY	Rate^a	Event	PY	Rate^a
Age, years
≤ 49	662	154,980	4.27	889	155,671	5.71	1.34 (1.21, 1.48)***	1.17 (1.04, 1.31)***
50–64	1174	127,099	9.24	1665	127,623	13.1	1.41 (1.31, 1.52)***	1.30 (1.19, 1.41)***
65+	1063	86,700	12.3	1427	92,682	15.4	1.25 (1.16, 1.36)***	1.11 (1.02, 1.21)***
Sex
Female	1758	211,353	8.32	2434	214,784	11.3	1.36 (1.28, 1.45)***	1.21 (1.14, 1.30)***
Male	1141	157,426	7.25	1547	161,192	9.60	1.32 (1.23, 1.43)***	1.14 (1.04, 1.24)***
Comorbidity ^c
No	1242	213,614	5.81	586	73,197	8.01	1.35 (1.22, 1.49)***	1.37 (1.24, 1.51)***
Yes	1657	155,164	10.7	3395	302,780	11.2	1.04 (0.98, 1.11)	1.14 (1.08, 1.21)***

Rate^a, incidence rate, per 1000 person-years; Crude HR, relative hazard ratio; Adjusted HR^b: multivariable analysis including age, sex, and comorbidities of diabetes, CAD, and lumbar disc herniation;
^cIndividuals with any comorbidity of diabetes, CAD, depression, and chronic kidney disease, obesity, cancer, and lumbar disc herniation were classified into the comorbidity group
***p < 0.001

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