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Fig. 2 | BMC Musculoskeletal Disorders

Fig. 2

From: Higher aggrecan 1-F21 epitope concentration in synovial fluid early after anterior cruciate ligament injury is associated with worse knee cartilage quality assessed by gadolinium enhanced magnetic resonance imaging 20 years later

Fig. 2

Adjusted linear regression analyses between molecular biomarkers and dGEMRIC. Molecular biomarkers in acute and chronic synovial fluid samples were used as prognostic variables for cartilage quality assessed by dGEMRIC 20 years post ACL injury. Squares: mean effect with size being proportional to number of available biomarker data. Grey area: highlights statistical significance with an alpha level of 0.05. Standardized effect: the estimate of the average change in dGEMRIC T1Gd (expressed as standard deviation) that corresponds to a 1 standard deviation change in the prognostic factor. 1-F21 agcan = 1-F21 epitope of aggrecan, ARGS agcan = ARGS neoepitope of aggrecan, COMP = cartilage oligomeric matrix protein, MMP-3 = matrix metalloproteinase 3, sGAG = sulfated glycosaminoglycans, TIMP-1 = tissue inhibitor of metalloproteinase 1. dGEMRIC medial + lateral = the sum of medial and lateral dGEMRIC values divided by 2

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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