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Table 2 Incidence and hazard ratios of osteoporotic hip fracture between patients with and without hepatic encephalopathy

From: Hepatic encephalopathy increases the risk of hip fracture: a nationwide cohort study

 

Hepatic encephalopathy

  

No

Yes

 

Event

PY

Ratea

Event

PY

Ratea

cHR

(95% CI)

aHR

(95% CI)

P-value

Overall

575

58,393

9.8

68

3337

20.4

2.15

((1.67,2.78)***

2.36

(1.82,3.05)***

< 0.001

Sex

 Female

332

22,154

15.0

41

1278

32.1

2.25

((1.62,3.13)***

2.39

(1.71,3.34)***

< 0.001

 Male

243

36,239

6.7

27

2058

13.1

2.00

((1.34,3.00)***

2.24

(1.49,3.36)***

< 0.001

Age, years

 50–64

105

28,340

3.7

24

1972

12.2

3.57

((2.27,5.60)***

2.87

(1.81,4.54)***

< 0.001

 65–79

350

25,837

13.5

34

1144

29.7

2.51

((1.76,3.60)***

2.42

(1.69,3.47)***

< 0.001

 80+

120

4216

28.5

10

221

45.3

1.52

((0.79,2.92)

1.49

(0.78,2.88)

0.056

Comorbidity

 Hypertension

408

32,778

12.4

49

1910

25.7

2.18

((1.62,2.95)***

2.44

(1.80,3.31)***

< 0.001

 Diabetes mellitus

277

23,738

11.7

30

1348

22.3

1.96

((1.34,2.87)***

2.09

(1.42,3.07)***

< 0.001

 Hyperlipidemia

145

14,205

10.2

25

1081

23.1

2.38

((1.55,3.65)***

2.68

(1.74,4.15)***

< 0.001

 Senile Cataract

204

13,964

14.6

21

828

25.3

1.77

((1.13,2.80)*

2.02

(1.28,3.20)**

< 0.001

 Gastric Ulcer

289

23,761

12.2

36

1432

25.1

2.07

((1.46,2.95)***

2.31

(1.62,3.30)***

< 0.001

 Cholangitis

27

1595

16.9

2

109

18.4

1.18

((0.27,5.07)

1.10

(0.23,5.32)

0.078

 Depression

66

5053

13.1

11

443

24.8

2.02

((1.06,3.84)*

2.19

(1.12,4.20)*

0.048

 Alcohol-related illnesses

79

10,429

7.6

13

1117

11.6

1.57

((0.87,2.83)

1.91

(1.03,3.49)*

0.047

  1. aHR adjusted hazard ratio, cHR crude hazard ratio, PY person-years
  2. *P < 0.05, **P < 0.01, ***P < 0.001
  3. ratea, incidence rate per 1000 person-years