Fig. 3

Graphs show longitudinal DCE-MRI parameters in the model and control groups of wistar rats. At 12 weeks,all the differences of K^trans (min^− 1),K_ep (min^− 1) and V_e values were not statistically significant between the model and control groups. Compared with control group, (a) the K^trans (min^− 1) was significantly increased at 17 weeks and 22 weeks in model group,while(b) K_ep (min^− 1) and (c) V_e were significantly increased only at 22 weeks