Skip to main content

Table 5 Biomarkers at the bone cartilage interface in AS

From: Bone phenotypes in rheumatology – there is more to bone than just bone

Biomarker Disease Levels compared to healthy Findings References
Bone turnover
 CTX-I Increased Associated with radiographic progression
No effect of anti-TNFα therapy
[229, 230, 233, 234]
 ICTP Increased  – [235]
 PINP No difference Correlated with radiographic progression of syndesmophytes and ankylosis [226, 229,230,231,232,233]
 Osteocalcin No or limited difference Associated with syndesmophytes and ankylosis [226, 229,230,231,232]
 BALP No or limited difference  – [226, 229,230,231,232,233]
Cartilage Turnover
 CTX-II Increased Correlated with change in clinical disease severity in response to anti-TNFα therapy [229, 236]
 C2M Increased  – [237]
 C2C No difference  – [238]
 PIIANP Increased  – [192]
 PIIBNP Increased  – [193]