From: Bone phenotypes in rheumatology – there is more to bone than just bone
Biomarker | Disease Levels compared to healthy | Findings | References |
---|---|---|---|
Bone turnover | |||
CTX-I | Increased | Associated with radiographic progression No effect of anti-TNFα therapy | |
ICTP | Increased | – | [235] |
PINP | No difference | Correlated with radiographic progression of syndesmophytes and ankylosis | |
Osteocalcin | No or limited difference | Associated with syndesmophytes and ankylosis | |
BALP | No or limited difference | – | |
Cartilage Turnover | |||
CTX-II | Increased | Correlated with change in clinical disease severity in response to anti-TNFα therapy | |
C2M | Increased | – | [237] |
C2C | No difference | – | [238] |
PIIANP | Increased | – | [192] |
PIIBNP | Increased | – | [193] |