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Table 4 Biomarkers at the bone cartilage interface in PsA

From: Bone phenotypes in rheumatology – there is more to bone than just bone

Biomarker

Disease Levels compared to healthy

Findings

References

Bone turnover

 CTX-I

Conflicting reports

[179, 185]

 ICTP

Conflicting reports

[179, 185, 186]

 Osteocalcin

Increased, but conflicting reports

[187, 188] [182]

 C1M

Increased

[186]

 BALP

Increased, but conflicting reports

[187, 188] [182]

Cartilage Turnover

 CTX-II

Increased

[189]

 C2M

No difference

[190]

 C2C

Increased

[191]

 PIIANP

Increased

[192]

 PIIBNP

Increased

[193]

 CPII

Increased

[191]

 COMP

Increased in synovial fluid compared to RA

No clear correlation with disease activity

[191, 194,195,196]