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Table 4 Biomarkers at the bone cartilage interface in PsA

From: Bone phenotypes in rheumatology – there is more to bone than just bone

Biomarker Disease Levels compared to healthy Findings References
Bone turnover
 CTX-I Conflicting reports [179, 185]
 ICTP Conflicting reports [179, 185, 186]
 Osteocalcin Increased, but conflicting reports [187, 188] [182]
 C1M Increased [186]
 BALP Increased, but conflicting reports [187, 188] [182]
Cartilage Turnover
 CTX-II Increased [189]
 C2M No difference [190]
 C2C Increased [191]
 PIIANP Increased [192]
 PIIBNP Increased [193]
 CPII Increased [191]
 COMP Increased in synovial fluid compared to RA No clear correlation with disease activity [191, 194,195,196]