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Table 3 Biomarkers at the bone cartilage interface in RA

From: Bone phenotypes in rheumatology – there is more to bone than just bone

Biomarker Disease Levels compared to healthy Findings References
Bone turnover
 CTX-I Conflicting Correlated with joint damage, radiographic progression and response to treatment [143,144,145,146]
 ICTP Increased Correlated with joint damage [145, 146]
 C1M Increased Correlate with joint damage (JSN, mtss) and radiographic progression [147] [85]
 Osteocalcin Reduced (in naïve comparedto healthy controls) Predictive of treatment response to anti-IL-6R therapy in combination withbiomarkers CTX-I and C2M [144, 148, 149]
Cartilage Turnover
 CTX-II Increased Associated with radiographic progression [150]
 C2M Low levels associated with anti-Il-6R treatment response by swollen andtender joint count in composite with CTX-I and osteocalcin [144]
 PIIANP decreased  – [151]
Synovium turnover
 C4M Increased Associated with anti-IL-6R treatment efficacy. Baseline levels associated withstructural progression by JSN and Sharp score [152]
  1. mtss Modified total Sharp score