TY - JOUR AU - Sogi, Yasuhito AU - Yabe, Yutaka AU - Hagiwara, Yoshihiro AU - Tsuchiya, Masahiro AU - Onoda, Yoshito AU - Sekiguchi, Takuya AU - Itaya, Nobuyuki AU - Yoshida, Shinichiro AU - Yano, Toshihisa AU - Suzuki, Kazuaki AU - Onoki, Takahiro AU - Itoi, Eiji PY - 2020 DA - 2020/11/19 TI - Joint hemorrhage accelerates cartilage degeneration in a rat immobilized knee model JO - BMC Musculoskeletal Disorders SP - 761 VL - 21 IS - 1 AB - Joint hemorrhage is caused by trauma, ligament reconstruction surgery, and bleeding disorders such as hemophilia. Recurrence of hemorrhage in the joint space induces hemosiderotic synovitis and oxidative stress, resulting in both articular cartilage degeneration and arthropathy. Joint immobilization is a common treatment option for articular fractures accompanied by joint hemorrhage. Although joint hemorrhage has negative effects on the articular cartilage, there is no consensus on whether a reduction in joint hemorrhage would effectively prevent articular cartilage degeneration. The purpose of this study was to investigate the effect of joint hemorrhage combined with joint immobilization on articular cartilage degeneration in a rat immobilized knee model. SN - 1471-2474 UR - https://doi.org/10.1186/s12891-020-03795-0 DO - 10.1186/s12891-020-03795-0 ID - Sogi2020 ER -