Fig. 4
From: Proteasome inhibitors reduce thrombospondin-1 release in human dysferlin-deficient myotubes
TSP-1 expression by dysf mut/mut myotubes treated with oprozomib, ixazomib and EB1089. a TSP-1 expression with treatment of oprozomib at 10 nM and EB1089 100 nM was significantly decreased compared to C- (non-treated dysf mut/mut myotubes), and the combination of both treatments was also significantly decreased compared to oprozomib treatment alone. b There were no significant differences in TSP-1 levels between ixazomib and EB1089 compared to non-treated myotubes. However, the combination of both treatments showed a significant reduction compared to non-treated myotubes. Data are represented as mean of 5 replicates ± standard deviation. Results were statistically analyzed using one-way Anova followed by Tukey post hoc test. Statistical significance was set at p < 0.05. **p < 0.01; ***p < 0.0001