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Table 2 Hazard ratio of overall survival for patients with Ewing sarcoma based on Cox regression

From: A nomogram for predicting overall survival in patients with Ewing sarcoma: a SEER-based study

Characteristics Univariate analysis 95% CI P value Multivariable analysis 95% CI P value
Hazard ratio Hazard ratio
Age (years)
  ≤ 18 Reference    Reference   
 19–27 1.928 1.200–3.097 0.007 1.778 1.092–2.895 0.021
  ≥ 28 5.324 3.434–8.254 <0.001 5.145 3.231–8.192 <0.001
Sex
 Male Reference    Not included   
 Female 1.026 0.700–1.502 0.897    
Race
 White Reference    Not included   
 Black 1.828 0.887–3.767 0.102    
 Others/unknown 1.075 0.560–2.066 0.827    
stage
 II Reference    Reference   
 III 2.022 0.276–14.793 0.488 2.545 0.289–28.446 0.400
 IV 3.266 2.142–4.977 <0.001 1.100 0.117–10.312 0.933
 Others/unknown 2.144 1.168–3.937 0.014 1.195 0.484–2.945 0.699
T stage
 T0-T1 Reference    Reference   
 T2 1.384 0.857–2.234 0.184 1.284 0.769–2.144 0.340
 T3 3.905 1.845–8.264 <0.001 1.367 0.558–3.347 0.494
 Tx 2.558 1.565–4.181 <0.001 1.453 0.731–2.888 0.286
N stage
 N0 Reference    Reference   
 N1 1.335 0.646–2.758 0.436 0.686 0.258–1.825 0.450
 Nx 3.188 1.912–5.312 <0.001 3.392 1.848–6.224 <0.001
M stage
 M0 Reference    Reference   
 M1 2.992 2.055–4.356 <0.001 1.981 0.205–19.147 0.555
Bone metastasis
 No/unknown Reference    Reference   
 Yes 3.476 2.271–5.320 <0.001 2.309 1.315–4.056 0.004
Brain metastasis
 No/unknown Reference    Not included   
 Yes 3.087 0.979–9.735 0.054    
Liver metastasis
 No/unknown Reference    Reference   
 Yes 8.918 2.801–28.390 <0.001 2.861 0.651–12.564 0.164
Lung metastasis
 No/unknown Reference    Reference   
 Yes 2.121 1.393–3.227 <0.001 1.226 0.699–2.148 0.477