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Table 1 Percent inhibition in disease parameters of individual and combination treatments

From: Repository corticotropin injection attenuates collagen-induced arthritic joint structural damage and has enhanced effects in combination with etanercept

Disease Parameter ETN 10 mg/kg RCI RCI 160 U/kg + ETN RCI 400 U/kg + ETN
160 U/kg 400 U/kg
Inflammation 9% 19%a 26%b 29%b 55%b
Pannus formation 24% 17% 52%b 54%b 71%b
Cartilage damage 22%a 6% 26%a 44%b 51%b
Bone resorption 24% 17% 52%b 55%b 71%b
Periosteal bone formation 15% 12% 32% 31% 44%c
Paw edema AUC (day 13–20) 19% 19% 38%b 45%b 57%b
Serum anti-CII antibodies 2% 30% 14% 56%d 50%c
  1. Ankles were examined microscopically by a board-certified veterinary pathologist and given a score of 0 to 5 (see Methods for additional details).
  2. a p ≤ 0.05 vs disease control group. b p ≤ 0.0001 vs disease control group. c p ≤ 0.01 vs disease control group. d p ≤ 0.001 vs disease control group. Analyzed by 2-way ANOVA followed by the Dunn’s multiple comparisons test (for inflammation, pannus formation, cartilage damage, bone resorption, and periosteal bone formation) or the Dunnett’s multiple comparisons test (for paw edema AUC and serum anti-CII antibodies)
  3. Abbreviations: ANOVA, analysis of variance; AUC, area under the curve; CII, collagen type II; ETN, etanercept; RCI, repository corticotropin injection