TY - JOUR AU - Decker, Dima A. AU - Higgins, Paul AU - Hayes, Kyle AU - Bollinger, Chris AU - Becker, Patrice AU - Wright, Dale PY - 2020 DA - 2020/08/31 TI - Repository corticotropin injection attenuates collagen-induced arthritic joint structural damage and has enhanced effects in combination with etanercept JO - BMC Musculoskeletal Disorders SP - 586 VL - 21 IS - 1 AB - Melanocortin receptor (MCR) agonists have anti-inflammatory and immunomodulatory properties mediated by receptors expressed on cells relevant to arthritis. Repository corticotropin injection (RCI; Acthar® Gel), an MCR agonist preparation, is approved as adjunctive therapy for rheumatoid arthritis (RA), but its mechanism of action in RA is unclear. This study explored the efficacy of RCI as monotherapy or adjunctive therapy with etanercept (ETN) in an established animal model of collagen-induced arthritis (CIA). SN - 1471-2474 UR - https://doi.org/10.1186/s12891-020-03609-3 DO - 10.1186/s12891-020-03609-3 ID - Decker2020 ER -