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Table 3 SIR and Cox model with time dependent covariates for the excess risk after 10 years follow-up comparing different types of fixations

From: A prospective study on cancer risk after total hip replacements for 41,402 patients linked to the Cancer registry of Norway

  #hips #cancers Total Before 10 years After 10 years Cox model with time-dep. covariatesa
SIR (95% CI) SIR (95% CI) SIR (95% CI) HR b (95% CI) P
Total: 41,402 6167 1.06 (1.03–1.09) 1.06 (1.03–1.09) 1.02 (0.97–1.07)    
Cemented 32,534 5060 1.05 (1.03–1.08) 1.06 (1.03–1.09) 0.99 (0.94–1.05) 1 (reference)
Uncemented 6679 743 1.08 (1.00–1.16) 1.04 (0.94–1.13) 1.16 (1.02–1.30) 1.24 (1.05–1.46) 0.009
Hybrid 2189 364 1.11 (0.99–1.22) 1.09 (0.95–1.22) 1.12 (0.91–1.33) 1.07 (0.85–1.35) 0.55
< 55 years: 3374 246 0.96 (0.84–1.08) 0.89 (0.74–1.04) 1.06 (0.86–1.26)    
Cemented 1138 89 1.09 (0.86–1.31) 1.04 (0.77–1.32) 1.16 (0.77–1.56) 1 (reference)
Uncemented 1967 139 0.89 (0.75–1.04) 0.80 (0.62–0.99) 1.00 (0.76–1.24) 1.19 (0.69–2.05) 0.54
Hybrid 269 18 0.96 (0.52–1.40) 0.85 (0.37–1.34) 1.27 (0.25–2.29) 1.31 (0.45–3.82) 0.62
55–64 years: 12,500 1664 1.06 (1.01–1.11) 1.00 (0.95–1.06) 1.16 (1.06–1.25)    
Cemented 8480 1119 1.02 (0.96–1.08) 0.97 (0.90–1.04) 1.11 (1.00–1.22) 1 (reference)
Uncemented 3219 418 1.15 (1.04–1.27) 1.08 (0.95–1.21) 1.29 (1.09–1.50) 1.07 (0.85–1.36) 0.56
Hybrid 801 127 1.15 (0.95–1.35) 1.13 (0.90–1.36) 1.16 (0.79–1.53) 0.93 (0.62–1.38) 0.71
65–74 years: 25,528 4257 1.07 (1.03–1.10) 1.09 (1.05–1.12) 0.96 (0.90–1.02)    
Cemented 22,916 3852 1.06 (1.03–1.10) 1.09 (1.05–1.13) 0.95 (0.89–1.01) 1 (reference)
Uncemented 1493 186 1.10 (0.94–1.26) 1.11 (0.93–1.29) 1.03 (0.72–1.35) 1.00 (0.71–1.43) 0.98
Hybrid 1119 219 1.10 (0.96–1.25) 1.09 (0.91–1.26) 1.09 (0.82–1.35) 1.12 (0.83–1.51) 0.46
Men: 13,954 2542 1.03 (0.99–1.07) 1.02 (0.97–1.07) 1,03 (0.95–1.10)    
Cemented 10,423 2037 1.02 (0.98–1.07) 1.02 (0.97–1.07) 0,99 (0.91–1.08) 1 (reference)
Uncemented 2748 343 1.04 (0.93–1.15) 0.98 (0.85–1.11) 1.15 (0.95–1.34) 1.41 (1.11–1.80) 0.004
Hybrid 783 162 1.13 (0.96–1.31) 1.11 (0.91–1.31) 1.15 (0.81–1.49) 1.11 (0.78–1.58) 0.58
Women: 27,448 3625 1.08 (1.05–1.12) 1.09 (1.05–1.13) 1.02 (0.96–1.08)    
Cemented 22,111 3023 1.08 (1.04–1.12) 1.09 (1.04–1.14) 1.00 (0.93–1.06) 1 (reference)
Uncemented 3931 400 1.12 (1.01–1.23) 1.09 (0.96–1.22) 1.17 (0.97–1.36) 1.09 (0.87–1.36) 0.47
Hybrid 1406 202 1.09 (0.94–1.24) 1.07 (0.89–1.24) 1.10 (0.80–1.39) 1.06 (0.78–1.43) 0.72
  1. a Adjusted for current age, gender, diagnosis, and a second primary or revision prosthesis operation
  2. b,c The estimates are hazard ratios (HR)