|
#hips
|
#cancers
|
Total
|
Before 10 years
|
After 10 years
|
Cox model with time-dep. covariatesa
|
---|
SIR (95% CI)
|
SIR (95% CI)
|
SIR (95% CI)
|
HR b
|
(95% CI)
|
P
|
---|
Total:
|
41,402
|
6167
|
1.06 (1.03–1.09)
|
1.06 (1.03–1.09)
|
1.02 (0.97–1.07)
| | | |
Cemented
|
32,534
|
5060
|
1.05 (1.03–1.08)
|
1.06 (1.03–1.09)
|
0.99 (0.94–1.05)
|
1
|
(reference)
|
–
|
Uncemented
|
6679
|
743
|
1.08 (1.00–1.16)
|
1.04 (0.94–1.13)
|
1.16 (1.02–1.30)
|
1.24
|
(1.05–1.46)
|
0.009
|
Hybrid
|
2189
|
364
|
1.11 (0.99–1.22)
|
1.09 (0.95–1.22)
|
1.12 (0.91–1.33)
|
1.07
|
(0.85–1.35)
|
0.55
|
< 55 years:
|
3374
|
246
|
0.96 (0.84–1.08)
|
0.89 (0.74–1.04)
|
1.06 (0.86–1.26)
| | | |
Cemented
|
1138
|
89
|
1.09 (0.86–1.31)
|
1.04 (0.77–1.32)
|
1.16 (0.77–1.56)
|
1
|
(reference)
|
–
|
Uncemented
|
1967
|
139
|
0.89 (0.75–1.04)
|
0.80 (0.62–0.99)
|
1.00 (0.76–1.24)
|
1.19
|
(0.69–2.05)
|
0.54
|
Hybrid
|
269
|
18
|
0.96 (0.52–1.40)
|
0.85 (0.37–1.34)
|
1.27 (0.25–2.29)
|
1.31
|
(0.45–3.82)
|
0.62
|
55–64 years:
|
12,500
|
1664
|
1.06 (1.01–1.11)
|
1.00 (0.95–1.06)
|
1.16 (1.06–1.25)
| | | |
Cemented
|
8480
|
1119
|
1.02 (0.96–1.08)
|
0.97 (0.90–1.04)
|
1.11 (1.00–1.22)
|
1
|
(reference)
|
–
|
Uncemented
|
3219
|
418
|
1.15 (1.04–1.27)
|
1.08 (0.95–1.21)
|
1.29 (1.09–1.50)
|
1.07
|
(0.85–1.36)
|
0.56
|
Hybrid
|
801
|
127
|
1.15 (0.95–1.35)
|
1.13 (0.90–1.36)
|
1.16 (0.79–1.53)
|
0.93
|
(0.62–1.38)
|
0.71
|
65–74 years:
|
25,528
|
4257
|
1.07 (1.03–1.10)
|
1.09 (1.05–1.12)
|
0.96 (0.90–1.02)
| | | |
Cemented
|
22,916
|
3852
|
1.06 (1.03–1.10)
|
1.09 (1.05–1.13)
|
0.95 (0.89–1.01)
|
1
|
(reference)
|
–
|
Uncemented
|
1493
|
186
|
1.10 (0.94–1.26)
|
1.11 (0.93–1.29)
|
1.03 (0.72–1.35)
|
1.00
|
(0.71–1.43)
|
0.98
|
Hybrid
|
1119
|
219
|
1.10 (0.96–1.25)
|
1.09 (0.91–1.26)
|
1.09 (0.82–1.35)
|
1.12
|
(0.83–1.51)
|
0.46
|
Men:
|
13,954
|
2542
|
1.03 (0.99–1.07)
|
1.02 (0.97–1.07)
|
1,03 (0.95–1.10)
| | | |
Cemented
|
10,423
|
2037
|
1.02 (0.98–1.07)
|
1.02 (0.97–1.07)
|
0,99 (0.91–1.08)
|
1
|
(reference)
|
–
|
Uncemented
|
2748
|
343
|
1.04 (0.93–1.15)
|
0.98 (0.85–1.11)
|
1.15 (0.95–1.34)
|
1.41
|
(1.11–1.80)
|
0.004
|
Hybrid
|
783
|
162
|
1.13 (0.96–1.31)
|
1.11 (0.91–1.31)
|
1.15 (0.81–1.49)
|
1.11
|
(0.78–1.58)
|
0.58
|
Women:
|
27,448
|
3625
|
1.08 (1.05–1.12)
|
1.09 (1.05–1.13)
|
1.02 (0.96–1.08)
| | | |
Cemented
|
22,111
|
3023
|
1.08 (1.04–1.12)
|
1.09 (1.04–1.14)
|
1.00 (0.93–1.06)
|
1
|
(reference)
|
–
|
Uncemented
|
3931
|
400
|
1.12 (1.01–1.23)
|
1.09 (0.96–1.22)
|
1.17 (0.97–1.36)
|
1.09
|
(0.87–1.36)
|
0.47
|
Hybrid
|
1406
|
202
|
1.09 (0.94–1.24)
|
1.07 (0.89–1.24)
|
1.10 (0.80–1.39)
|
1.06
|
(0.78–1.43)
|
0.72
|
- a Adjusted for current age, gender, diagnosis, and a second primary or revision prosthesis operation
- b,c The estimates are hazard ratios (HR)