Table 4 Clinical improvement as percent of changes in mean outcome scores over the time-points

 Before

9.74 (0.22)

2.72 (0.19)

29.92 (1.04)

42.38 (1.24)

5.08 (0.16)

1.67 (0.09)

5.68 (0.11)

12.42 (0.26)

7.82 (0.18)

 2 months

5.00 (0.27)

2.65 (0.17)

19.46 (1.12)

26.03 (1.4)

3.95 (0.19)

1.21 (0.09)

4.45 (0.19)

9.60 (0.40)

2.69 (0.22)

 6 months

5.05 (0.28)

1.41 (0.19)

17.62 (1.18)

24.08 (1.55)

3.49 (0.22)

1.38 (0.11)

4.10 (0.19)

8.97 (0.44)

3.46 (0.17)

Mean Difference^a (SD)

−4.7 (0.32)

−1.3 (0.26)

−12.30 (0.9)

−18.30 (1.23)

−1.6 (0.23)

−0.28 (0.1)

−1.57 (0.2)

−3.45 (0.38)

−4.36 (0.27)

Change^b (%) from baseline [SD]

47.77 [2.96]

58.16 [5.56]

41.82 [3.17]

43.76 [3.06]

37.38 [3.63]

29.91 [5.94]

28.29 [3.23]

29.93 [2.77]

55.17 [3.20]

Success Rate^c (Number) [%]

31 [79.5]

30 [83.3]

28 [71.8]

25 [64.1]

24 [61.5]

18 [46.2]

13 [33.3]

18 [46.2]

34 [87.2]

*P value

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

 Before

9.28 (0.26)

2.65 (0.19)

29.88 (1.24)

41.33 (1.65 V)

5.53 (0.15)

1.58 (0.13)

5.63 (0.12)

12.50 (0.36)

8.15 (0.17)

 2 months

4.83 (0.23)

1.05 (0.16)

18.40 (1.01)

25.00 (1.33)

3.50 (0.17)

1.15 (0.10)

4.18 (0.15)

8.93 (0.34)

2.65 (0.18)

 6 months

5.30 (0.24)

1.00 (0.14)

19.00 (1.05)

26.55 (1.43)

3.75 (0.19)

1.28 (0.11)

4.65 (0.16)

9.93 (0.42)

3.65 (0.18)

Mean Difference^a (SD)

−3.97 (0.25)

−1.65 (0.14)

−10.87 (1.07)

−14.77 (1.05)

−1.77 (0.19)

−0.30 (0.11)

−0.975 (0.13)

−2.57 (0.28)

−4.50 (0.25)

Change^b (%) from baseline [SD]

42.56 [2.26]

63.20 [4.72]

36.55 [2.52]

35.62 [2.33]

32.62 [2.98]

17.98 [5.12]

19.03 [2.23]

21.21 [2.20]

54.71 [2.67]

Success Rate^c (Number) [%]

34 [85]

34 [87.2]

27 [67.5]

29 [72.5]

21 [52.5]

11 [28.9]

7 [17.5]

9 [22.5]

36 [90]

*P value

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001^#

< 0.001

**P value

0.66

0.21

0.94

0.94

0.69

0.53

0.70

0.80

0.48