Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population

Table 5 Association between CARMEN variants and ONFH risk stratified by necrotic sites

SNP	Model	Genotype	Frequency		Without adjustment		With adjustment
SNP	Model	Genotype	Case	Control	OR(95%CI)	p-value	OR(95%CI)	p-value
rs12654195	codominant	G/G	22	60	1		1
		G/T	111	174	1.06 (0.76–1.48)	0.737	1.05 (0.75–1.47)	0.780
		T/T	109	181	0.61 (0.35–1.05)	0.073	0.61 (0.35–1.05)	0.074
	dominant	G/G	22	60	1		1
		G/T-T/T	220	355	0.94 (0.69–1.30)	0.722	0.94 (0.68–1.29)	0.688
	recessive	G/G-G/T	133	234	1		1
		T/T	109	181	0.59 (0.35–0.99)	0.046	0.60 (0.35–0.99)	0.049
	log-additive	–	142	174	0.86 (0.68–1.09)	0.219	0.86 (0.68–1.09)	0.211

95%CI 95% Confidence interval; OR Odds ratio; SNP Single-nucleotide polymorphism
p-value: Calculated by Pearson χ² test
Bold type indicates statistical significance (p < 0.05)

ISSN: 1471-2474