Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population

Table 4 Association between CARMEN variants and ONFH risk stratified by age

SNP	Model	Genotype	>45ys		≤45ys
SNP	Model	Genotype	OR(95%CI)	p-value	OR(95%CI)	p-value
rs13177623	Allele	A	1		1
		G	0.97 (0.69–1.36)	0.868	0.73 (0.53–1.00)	0.047
	codominant	A/A	1		1
		A/G	1.15 (0.73–1.81)	0.557	0.77 (0.50–1.19)	0.239
		G/G	0.71 (0.27–1.84)	0.475	0.39 (0.18–0.87)	0.022
	dominant	A/A	1		1
		A/G-G/G	1.08 (0.7–1.68)	0.726	0.69 (0.45–1.03)	0.072
	recessive	A/A-A/G	1		1
		G/G	0.66 (0.26–1.66)	0.377	0.44 (0.20–0.96)	0.038
	log-additive	–	0.99 (0.69–1.41)	0.936	0.69 (0.50–0.95)	0.021
rs12654195	Allele	G	1		1
		T	1.03 (0.74–1.44)	0.868	0.69 (0.51–0.93)	0.015
	codominant	G/G	1		1
		G/T	1.47 (0.92–2.34)	0.108	0.74 (0.47–1.15)	0.176
		T/T	0.65 (0.27–1.59)	0.349	0.41 (0.21–0.79)	0.008
	dominant	G/G	1		1
		G/T-T/T	1.31 (0.83–2.05)	0.243	0.64 (0.42–0.97)	0.033
	recessive	G/G-G/T	1		1
		T/T	0.53 (0.23–1.25)	0.147	0.47 (0.25–0.88)	0.019
	log-additive	–	1.05 (0.74–1.49)	0.796	0.67 (0.49–0.90)	0.008
rs11168100	Allele	A	1		1
		T	1.00 (0.72–1.39)	1.000	0.75 (0.55–1.01)	0.061
	codominant	A/A	1		1
		A/T	1.39 (0.88–2.21)	0.160	0.71 (0.46–1.11)	0.132
		T/T	0.63 (0.26–1.52)	0.302	0.55 (0.28–1.08)	0.084
	dominant	A/A	1		1
		A/T-T/T	1.24 (0.8–1.94)	0.340	0.67 (0.45–1.02)	0.059
	recessive	A/A-A/T	1		1
		T/T	0.53 (0.23–1.23)	0.136	0.64 (0.34–1.23)	0.181
	log-additive	–	1.01 (0.72–1.43)	0.946	0.73 (0.54–0.99)	0.045

95%CI 95% Confidence interval; OR Odds ratio; SNP Single-nucleotide polymorphism
p-value: Calculated by Pearson χ² test
Bold type indicates statistical significance (p < 0.05)

ISSN: 1471-2474