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Table 4 Association between CARMEN variants and ONFH risk stratified by age

From: Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population

SNP Model Genotype >45ys ≤45ys
OR(95%CI) p-value OR(95%CI) p-value
rs13177623 Allele A 1   1  
   G 0.97 (0.69–1.36) 0.868 0.73 (0.53–1.00) 0.047
  codominant A/A 1   1  
   A/G 1.15 (0.73–1.81) 0.557 0.77 (0.50–1.19) 0.239
   G/G 0.71 (0.27–1.84) 0.475 0.39 (0.18–0.87) 0.022
  dominant A/A 1   1  
   A/G-G/G 1.08 (0.7–1.68) 0.726 0.69 (0.45–1.03) 0.072
  recessive A/A-A/G 1   1  
   G/G 0.66 (0.26–1.66) 0.377 0.44 (0.20–0.96) 0.038
  log-additive 0.99 (0.69–1.41) 0.936 0.69 (0.50–0.95) 0.021
rs12654195 Allele G 1   1  
   T 1.03 (0.74–1.44) 0.868 0.69 (0.51–0.93) 0.015
  codominant G/G 1   1  
   G/T 1.47 (0.92–2.34) 0.108 0.74 (0.47–1.15) 0.176
   T/T 0.65 (0.27–1.59) 0.349 0.41 (0.21–0.79) 0.008
  dominant G/G 1   1  
   G/T-T/T 1.31 (0.83–2.05) 0.243 0.64 (0.42–0.97) 0.033
  recessive G/G-G/T 1   1  
   T/T 0.53 (0.23–1.25) 0.147 0.47 (0.25–0.88) 0.019
  log-additive 1.05 (0.74–1.49) 0.796 0.67 (0.49–0.90) 0.008
rs11168100 Allele A 1   1  
   T 1.00 (0.72–1.39) 1.000 0.75 (0.55–1.01) 0.061
  codominant A/A 1   1  
   A/T 1.39 (0.88–2.21) 0.160 0.71 (0.46–1.11) 0.132
   T/T 0.63 (0.26–1.52) 0.302 0.55 (0.28–1.08) 0.084
  dominant A/A 1   1  
   A/T-T/T 1.24 (0.8–1.94) 0.340 0.67 (0.45–1.02) 0.059
  recessive A/A-A/T 1   1  
   T/T 0.53 (0.23–1.23) 0.136 0.64 (0.34–1.23) 0.181
  log-additive 1.01 (0.72–1.43) 0.946 0.73 (0.54–0.99) 0.045
  1. 95%CI 95% Confidence interval; OR Odds ratio; SNP Single-nucleotide polymorphism
  2. p-value: Calculated by Pearson χ2 test
  3. Bold type indicates statistical significance (p < 0.05)