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Fig. 2 | BMC Musculoskeletal Disorders

Fig. 2

From: Bilobalide protects against ischemia/reperfusion-induced oxidative stress and inflammatory responses via the MAPK/NF-κB pathways in rats

Fig. 2

Bilobalide reduced NADPH oxidase activity and F2-isoprostane and MDA levels and enhanced SOD, CAT, and GSH-Px activity in skeletal muscle following I/R. The activity of NADPH oxidase (a) and the levels of F2-isoprostanes (b) and MDA (c) were increased in muscle tissue after I/R injury, while the activity of SOD (d), CAT (e), and GSH-Px (f) was decreased. Bilobalide treatment reversed the injury-induced changes. *P < 0.05 and **p < 0.01 compared with the sham group; #p < 0.05 compared with the I/R group; ns = not significant compared with the I/R + bilobalide-low group. n = 8 per group

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