Table 1 studies on the influence of biologic DMARDs on SSI rate
Author, year | Type of surgery | Number of operations | bDMARD | Main finding in patients not stopping bDMARDs |
|---|---|---|---|---|
Bibbo & Goldberg, 2004 [10] | Foot and ankle surgery | 31 | Continued treatment perioperatively | SSI rate decreased |
Talwalkar et al., 2005 [11] | Various orthopedic surgeries | 11 | TNF inhibitors discontinued 2–4 weeks prior to surgery or continued treatment perioperatively | SSI rate unchanged |
Wendling et al., 2005 [12] | Various orthopedic surgeries | 50 | TNF inhibitors discontinued 2–4 weeks prior to surgery or continued treatment perioperatively | SSI rate unchanged |
Giles et al., 2006 [13] | Various orthopedic surgeries | 91 | Continued treatment perioperatively | SSI rate increased |
Broeder et al., 2007 [14] | Various orthopedic surgeries | 1219 | TNF inhibitors discontinued 4 t1/2 prior to surgery or continued treatment perioperatively | SSI rate unchanged |
Ruyssen-Witrand et al., 2007 [15] | Various surgeries | 127 | Variable timing for discontinuation prior to surgery | SSI rate unchanged |
Gilson et al., 2010 [16] | Total joint replacement | 60 | Cases treated with TNF inhibitors included | SSI rate increased |
Kawakami et al., 2010 [17] | Various orthopedic surgeries | 128 | TNF inhibitors discontinued 2–4 weeks prior to surgery and restarted if no signs of infection | SSI rate increased |
Suzuki et al., 2011 [18] | Arthroplasties | 1626 | Continued treatment perioperatively | SSI rate increased |
Momahara et al., 2011 [19] | THA1 and TKA2 | 420 | TNF inhibitors discontinued 2–4 weeks prior to surgery, cDMARDs continued | SSI rate increased |
Berthold et al., 2013 [20] | Various orthopedic and hand surgeries | 1596 | TNF inhibitors discontinued 2–4 weeks prior to surgery or continued treatment perioperatively | SSI rate increased |
Tada et al., 2016 [21] | Various orthopedic surgeries | 332 | TNF inhibitors discontinued 2–4 weeks prior to surgery, cDMARDs continued | SSI rate unchanged |
Hayashi et al., 2017 [22] | THAa | 99 | Variable timing for discontinuation or no discontinuation prior to surgery | late SSI rate increased |
Salt et al., 2017 [23] | THAa, TKAb and total shoulder arthroplasty | 2212 | Variable timing for discontinuation or no discontinuation prior to surgery | SSI rate unchanged |