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Table 1 studies on the influence of biologic DMARDs on SSI rate

From: Anti-rheumatic treatment and prosthetic joint infection: an observational study in 494 elective hip and knee arthroplasties

Author, year Type of surgery Number of operations bDMARD Main finding in patients not stopping bDMARDs
Bibbo & Goldberg, 2004 [10] Foot and ankle surgery 31 Continued treatment perioperatively SSI rate decreased
Talwalkar et al., 2005 [11] Various orthopedic surgeries 11 TNF inhibitors discontinued 2–4 weeks prior to surgery or continued treatment perioperatively SSI rate unchanged
Wendling et al., 2005 [12] Various orthopedic surgeries 50 TNF inhibitors discontinued 2–4 weeks prior to surgery or continued treatment perioperatively SSI rate unchanged
Giles et al., 2006 [13] Various orthopedic surgeries 91 Continued treatment perioperatively SSI rate increased
Broeder et al., 2007 [14] Various orthopedic surgeries 1219 TNF inhibitors discontinued 4 t1/2 prior to surgery or continued treatment perioperatively SSI rate unchanged
Ruyssen-Witrand et al., 2007 [15] Various surgeries 127 Variable timing for discontinuation prior to surgery SSI rate unchanged
Gilson et al., 2010 [16] Total joint replacement 60 Cases treated with TNF inhibitors included SSI rate increased
Kawakami et al., 2010 [17] Various orthopedic surgeries 128 TNF inhibitors discontinued 2–4 weeks prior to surgery and restarted if no signs of infection SSI rate increased
Suzuki et al., 2011 [18] Arthroplasties 1626 Continued treatment perioperatively SSI rate increased
Momahara et al., 2011 [19] THA1 and TKA2 420 TNF inhibitors discontinued 2–4 weeks prior to surgery, cDMARDs continued SSI rate increased
Berthold et al., 2013 [20] Various orthopedic and hand surgeries 1596 TNF inhibitors discontinued 2–4 weeks prior to surgery or continued treatment perioperatively SSI rate increased
Tada et al., 2016 [21] Various orthopedic surgeries 332 TNF inhibitors discontinued 2–4 weeks prior to surgery, cDMARDs continued SSI rate unchanged
Hayashi et al., 2017 [22] THAa 99 Variable timing for discontinuation or no discontinuation prior to surgery late SSI rate increased
Salt et al., 2017 [23] THAa, TKAb and total shoulder arthroplasty 2212 Variable timing for discontinuation or no discontinuation prior to surgery SSI rate unchanged
  1. aTotal hip arthroplasty, bTotal knee arthroplasty