1 year follow-up | 5 years’ follow-up | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Np | Nr | Incidence (95% CI) | SHR (95%CI) | p value | Np | Nr | incidence (95% CI) | SHR (95% CI) | P value | |
Burden of comorbidity | 0.021 | 0.030 | ||||||||
0 comorbidities | 6270 | 61 | 0.92 (0.71–1.18) | 1.00 | 3391 | 79 | 2.45 (2.06–2.88) | 1.00 | ||
1 comorbidity | 5501 | 70 | 1.17 (0.92–1.47) | 1.29 (0.91–1.84) | 2717 | 56 | 2.33 (1.95–2.77) | 1.09 (0.85–1.40) | ||
> =2 comorbidities | 4388 | 68 | 1.39 (1.10–1.76) | 1.51 (1.05–2.15) | 1927 | 53 | 2.94 (2.44–3.50) | 1.32 (1.03–1.71) | ||
Uncomplicated hypertension | 7161 | 100 | 1.29 (1.06–1.56) | 1.21 (0.91–1.62) | 0.189 | 3448 | 78 | 2.60 (2.23–3.00) | 1.12 (0.91–1.38) | 0.276 |
Uncomplicated diabetes | 1949 | 31 | 1.43 (0.99–2.00) | 1.30 (0.89–1.92) | 0.177 | 901 | 24 | 2.91 (2.21–3.76) | 1.25 (0.94–1.67) | 0.130 |
Obesity | 1072 | 23 | 1.90 (1.24–2.79) | 1.81 (1.17–2.80) | 0.007 | 479 | 21 | 4.39 (3.21–5.84) | 1.80 (1.31–2.47) | < 0.001 |
Depression | 1030 | 15 | 1.32 (0.77–2.12) | 1.16 (0.69–1.97) | 0.575 | 455 | 16 | 3.35 (2.30–4.72) | 1.28 (0.89–1.85) | 0.185 |
Chronic pulmonary disease | 1270 | 20 | 1.42 (0.90–2.16) | 1.32 (0.83–2.07) | 0.240 | 564 | 11 | 2.52 (1.74–3.54) | 1.07 (0.74–1.54) | 0.729 |
Hypothyroidism | 668 | 8 | 1.08 (0.51–2.05) | 0.92 (0.45–1.90) | 0.825 | 262 | 6 | 2.44 (1.36–4.05) | 0.87 (0.51–1.50) | 0.625 |
Deficiency anemia | 421 | 6 | 1.28 (0.54–2.65) | 1.14 (0.51–2.53) | 0.752 | 187 | 6 | 2.91 (1.58–4.90) | 1.26 (0.71–2.23) | 0.421 |
Renal failure | 323 | 4 | 1.04 (0.35–2.51) | 0.85 (0.31–2.33) | 0.753 | 100 | 2 | 1.84 (0.75–3.84) | 0.84 (0.39–1.89) | 0.667 |
Hypertension with complications | 254 | 1 | 0.33 (0.03–1.72) | 0.27 (0.04–1.94) | 0.192 | 69 | 1 | 0.75 (1.50–2.51) | 0.36 (0.09–1.45) | 0.151 |
Valvular disease | 259 | 2 | 0.69 (0.14–2.31) | 0.55 (0.14–2.20) | 0.399 | 113 | 0 | NR | NC | NC |
Rheumatoid arthritis | 249 | 3 | 1.06 (0.30–2.87) | 0.93 (0.30–2.90) | 0.898 | 101 | 4 | 2.88 (1.27–5.62) | 1.16 (0.55–2.45) | 0.690 |
Other neurological disorders | 212 | 3 | 1.29 (0.36–3.49) | 1.17 (0.38–3.67) | 0.780 | 88 | 2 | 2.23 (0.84–4.85) | 1.07 (0.44–2.59) | 0.882 |
Liver disease | 245 | 2 | 0.71 (0.14–2.38) | 0.71 (0.18–2.87) | 0. 630 | 106 | 5 | 3.42 (1.68–6.69) | 1.23 (0.59–2.59) | 0.581 |
Congestive heart failure | 131 | 2 | 1.36 (0.27–4.42) | 1.10 (0.27–4.51) | 0. 895 | 52 | 0 | NR | NC | NC |
Peripheral vascular disorders | 143 | 3 | 1.85 (0.51–4.93) | 1.73 (0.54–5.40) | 0. 349 | 67 | 4 | 5.39 (2.31–10.38) | 2.24 (1.06–4.74) | 0.034 |
Solid tumor | 87 | 1 | 1.08 (0.09–5.25) | 0.87 (0.12–6.13) | 0. 885 | 40 | 1 | 2.20 (0.42–6.97) | 1.01 (0.25–4.06) | 0.987 |
Diabetes with complications | 55 | 0 | NR | NC | NC | 22 | 0 | NR | NC | NC |
Coagulopathy | 71 | 0 | NR | NC | NC | 37 | 0 | NR | NC | NC |
Blood loss anemia | 65 | 0 | NR | NC | NC | 39 | 0 | NR | NC | NC |
Fluid and electrolyte disorders | 113 | 1 | 0.80 (0.07–3.99) | 0.68 (0.10–4.81) | 0.701 | 47 | 1 | 1.67 (0.32–5.36) | 0.77 (0.19–3.10) | 0.715 |
Alcohol abuse | 110 | 2 | 1.69 (0.33–5.42) | 1.81 (0.47–7.23) | 0.404 | 48 | 0 | NR | NC | NC |
Psychoses | 65 | 2 | 2.72 (0.52–8.49) | 2.62 (0.65–10.63) | 0.176 | 17 | 2 | 5.88 (1.89–13.23) | 2.77 (1.03–7.49) | 0.044 |
Paralysis | 35 | 1 | 2.63 (0.20–11.79) | 2.46 (0.36–16.87) | 0.375 | 14 | 1 | 5.58 (1.00–16.41) | 2.55 (0.63–10.28) | 0.188 |
Pulmonary circulation disorders | 17 | 0 | NR | NC | NC | 9 | 0 | NR | NC | NC |
Lymphoma | 16 | 1 | 6.25 (0.41–24.69) | 5.32 (0.75–37.33) | 0.092 | 4 | 0 | NR | NC | NC |
Peptic ulcer disease | 3 | 0 | NR | NC | NC | 3 | 0 | NR | NC | NC |
Drug abuse | 23 | 0 | NR | NC | NC | 10 | 0 | NR | NC | NC |
Metastatic cancer | 5 | 1 | 10.0 (0.57–35.81) | 12.23 (1.46–102.46) | 0.021 | 3 | 0 | NR | NC | NC |
Weight loss | 6 | 0 | NR | NC | NC | 2 | 0 | NR | NC | NC |
AIDS | 14 | 1 | 7,14 (0.45–27.52) | 8.17 (0.82–56.81) | 0.089 | 6 | 0 | NR | NC | NC |