Table 3 Cumulative incidence of revision at 1 and 5 years’ follow-up and effect of comorbidities from the Elixhauser index on the risk of revision in Total Knee Arthroplasty (TKA)

Burden of comorbidity

0.008

0.403

 0 comorbidities

0.77 (0.63–0.92)

1.00

3.74 (3.40–4.10)

1.00

 1 comorbidity

0.84 (0.71–0.99)

1.18 (0.93–1.53)

3.48 (3.18–3.79)

1.04 (0.92–1.19)

 > =2 comorbidities

0.97 (0.83–1.13)

1.39 (1.09–1.78)

3.47 (3.17–3.79)

1.06 (0.93–1.20)

Uncomplicated hypertension

0.88 (0.77–1.00)

1.13 (0.93–1.37)

0.214

3.38 (3.14–3.63)

1.03 (0.93–1.15)

0.549

Uncomplicated diabetes

0.79 (0.61–1.01)

0.92 (0.70–1.21)

0.541

3.17 (2.74–3.62)

0.91 (0.78–1.06)

0.216

Obesity

1.29 (1.00–1.63)

1.53 (1.17–1.99)

0.002

3.78 (3.22–4.40)

0.97 (0.82–1.14)

0.711

Depression

0.87 (0.63–1.17)

1.08 (0.77–1.51)

0.651

3.93 (3.30–4.61)

1.06 (0.89–1.27)

0.484

Chronic pulmonary disease

0.82 (0.57–1.14)

0.95 (0.66–1.36)

0.783

3.25 (2.68–3.90)

1.01 (0.83–1.23)

0.933

Hypothyroidism

0.85 (0.56–1.24)

1.12 (0.73–1.71)

0.603

3.78 (3.02–4.67)

1.04 (0.83–1.30)

0.724

Deficiency anemia

1.58 (0.96–4.46)

1.92 (1.18–3.11)

0.008

3.34 (2.32–4.65)

1.09 (0.77–1.56)

0.615

Renal failure

1.02 (0.51–1.88)

1.25 (0.64–2.42)

0.515

2.40 (1.46–3.72)

0.98 (0.61–1.57)

0.938

Hypertension with complications

1.03 (0.511.89)

1.35 (0.70–2.61)

0.376

2.38 (1.41–3.75)

0.94 (0.58–1.53)

0.815

Valvular disease

1.19 (0.61–2.11)

1.61 (0.85–3.03)

0.144

2.66 (1.64–4.07)

0.94 (0.60–1.49)

0.803

Rheumatoid arthritis

1.27 (0.60–2.39)

1.37 (0.68–2.78)

0.379

3.65 (2.20–5.65)

0.90 (0.57–1.44)

0.673

Other neurological disorders

1.04 (0.47–2.06)

1.23 (0.58–2.59)

0.590

3.19 (1.98–4.85)

1.01 (0.64–1.60)

0.951

Liver disease

2.29 (1.34–3.66)

2.50 (1.49–4.20)

0.001

5.51 (3.81–7.66)

1.60 (1.11–2.29)

0.011

Congestive heart failure

0.66 (0.18–1.80)

0.88 (0.28–2.74)

0.882

2.00 (0.94–3.78)

0.70 (0.35–1.39)

0.306

Peripheral vascular disorders

1.11 (0.37–2.67)

1.35 (0.51–3.62)

0.545

3.62 (1.90–6.21)

1.16 (0.64–2.09)

0.626

Solid tumor

0.49 (0.05–2.50)

0.53 (0.08–3.79)

0.530

1.20 (0.23–3.97)

0.38 (0.10–1.57)

0.187

Diabetes with complications

0.97 (0.19–3.20)

1.08 (0.27–4.34)

0.911

5.71 (2.91–9.86)

1.82 (0.98–3.38)

0.057

Coagulopathy

0.93 (0.19–3.06)

1.10 (0.27–4.42)

0.896

1.46 (0.40–3.92)

0.53 (0.17–1.67)

0.280

Blood loss anemia

0.93 (0.19–3.07)

0.75 (0.19–3.12)

0.709

6.56 (3.56–10.80)

1.54 (0.87–2.77)

0.141

Fluid and electrolyte disorders

0.50 (0.05–2.58)

0.57 (0.08–4.12)

0.575

2.73 (1.03–5.89)

0.91 (0.37–2.18)

0.841

Alcohol abuse

1.07 (0.21–3.52)

0.85 (0.21–3.48)

0.827

3.79 (1.54–7.69)

0.91 (0.37–2.23)

0.841

Psychosis

NR

NC

NC

2.49 (0.67–6.58)

0.60 (0.19–1.86)

0.378

Paralysis

2.36 (0.45–7.42)

2.67 (0.76–10.78)

0.169

11.79 (4.98–21.78)

3.14 (1.49–6.60)

0.003

Pulmonary circulation disorders

1.41 (0.12–6.72)

1.87 (0.26–13.46)

0.533

3.09 (0.58–9.58)

1.05 (0.25–4.30)

0.951

Lymphoma

NR

NC

NC

3.49 (0.26–15.09)

1.16 (0.17–8.10)

0.881

Peptic ulcer disease

3.57 (0.26–15.41)

3.25 (0.45–23.51)

0.243

NR

NC

NC

Drug abuse

NR

NC

NC

NR

NC

NC

Metastatic cancer

NR

NC

NC

NR

NC

NC

Weight loss

NR

NC

NC

11.11 (0.6–38.77)

3.32 (0.46–23.81)

0.232

AIDS

NR

NC

NC

NR

NC

NC