Table 2 Comparison of diagnostic tests for the diagnosis of periprosthetic joint infection in 107 patients
From: Thermogenic diagnosis of periprosthetic joint infection by microcalorimetry of synovial fluid
Positive test | No. patients | Aseptic failure (n = 61) | PJI (n = 46) | Sensitivity % (CI 95%) | Specificity % (CI 95%) | PPV % (CI 95%) | NPV % (CI 95%) | Accuracy % |
|---|---|---|---|---|---|---|---|---|
Positive preoperative test | ||||||||
Leukocyte count or percentage of granulocytes | 72 | 2/37 | 28/35 | 80 (67–94) | 95 (87–101) | 93 (84–102) | 83 (72–95) | 88 |
Synovial fluid culture | 107 | 0 | 18 | 39 (25–53) | 100 (100) | 100 (100) | 69 (59–78) | 74 |
Synovial fluid microcalorimetry | 107 | 1 | 18 | 39 (25–53) | 98 (95–102) | 95 (85–105) | 68 (59–78) | 73 |
Positive intraoperative test | ||||||||
Periprosthetic tissue histology | 48 | 0/21 | 20/27 | 74 (58–91) | 100 (100) | 100 (100) | 75 (59–91) | 85 |
Periprosthetic tissue culture | 61 | 0/28 | 15/33 | 46 (29–63) | 100 (100) | 100 (100) | 61 (47–75) | 71 |
Sonication fluid culture | 28 | 0/11 | 10/17 | 59 (35–82) | 100 (100) | 100 (100) | 61 (39–84) | 75 |