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Table 2 Comparison of diagnostic tests for the diagnosis of periprosthetic joint infection in 107 patients

From: Thermogenic diagnosis of periprosthetic joint infection by microcalorimetry of synovial fluid

Positive testNo. patientsAseptic failure (n = 61)PJI
(n = 46)
Sensitivity % (CI 95%)Specificity % (CI 95%)PPV
% (CI 95%)
NPV
% (CI 95%)
Accuracy %
Positive preoperative test
 Leukocyte count or percentage of granulocytes722/3728/3580 (67–94)95 (87–101)93 (84–102)83 (72–95)88
 Synovial fluid culture10701839 (25–53)100 (100)100 (100)69 (59–78)74
 Synovial fluid microcalorimetry10711839 (25–53)98 (95–102)95 (85–105)68 (59–78)73
Positive intraoperative test
 Periprosthetic tissue histology480/2120/2774 (58–91)100 (100)100 (100)75 (59–91)85
 Periprosthetic tissue culture610/2815/3346 (29–63)100 (100)100 (100)61 (47–75)71
 Sonication fluid culture280/1110/1759 (35–82)100 (100)100 (100)61 (39–84)75
  1. Where the denominator is shown, data were not available for all cases. PJI periprosthetic joint infection, PPV positive predictive value, NPV negative predictive value, 95% CI 95% confidence interval