Fig. 2
From: Understanding cartilage protection in OA and injury: a spectrum of possibilities
Assumed outcomes based on three different possible scenarios using an osteoarthritic model of PTOA or a FTCD cartilage injury model. In the context of indirect cartilage damage (OA model), one can analyze whether the treatment of choice is capable of attenuating or preventing OA development and cartilage degeneration (i.e., chondroprotection) when compared to untreated controls. However, the endogenous regenerative potential of the strain or species might interfere with the assumed outcome. Conversely, when using a direct cartilage injury model, one can investigate the mechanism underlying the endogenous regenerative ability, as well as to infer the efficacy of treatment of interest in enhancing cartilage regeneration