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Table 4 Effect of OVX and OVXG on the lipidome of sheep in the long-term analysis

From: Effects of short- and long-term glucocorticoid-induced osteoporosis on plasma metabolome and lipidome of ovariectomized sheep

m/z Lipid class OVX vs Control OVXG5 vs OVX OVXG2 vs OVXG5 p
FC FC FC FC FC FC FC FC FC FC FC FC FC FC FC    
1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 Trt Time Int
725.492 CL 72:6 1.20 0.91 1.16 0.98 1.05 0.89 0.96 0.99 1.06 0.90 1.06 1.05 0.91 0.90 1.04 0.018 0.082 0.023
752.511 CL 76:7 1.15 0.89 1.21 0.87 1.11 0.95 0.82 0.94 1.15 0.75 1.10 1.09 0.82 0.94 1.17 0.088 0.023 0.016
726.496 CL 72:5 1.19 0.91 1.19 0.95 1.02 0.88 0.98 0.87 1.06 0.88 1.19 1.05 1.01 0.97 1.05 0.03 0.026 0.018
751.518 CL 76:8 1.23 0.92 1.26 1.02 1.12 0.88 0.98 0.92 1.07 0.84 1.27 0.87 0.90 0.86 1.03 0.011 0.06 0.042
800.511 CL 84:15 1.15 0.85 1.16 0.97 1.07 0.92 0.93 0.87 0.99 0.88 1.03 1.26 1.10 0.93 1.04 0.027 0.06 0.005
686.546 CerP 39:1 1.21 0.91 1.21 1.02 1.09 0.97 0.93 0.99 1.08 0.80 1.08 1.22 0.86 0.83 1.13 0.042 0.071 0.014
660.543 CerP 37:0 1.17 0.93 1.16 0.99 1.10 0.94 0.91 0.88 1.04 0.92 1.04 1.13 0.91 0.99 1.00 0.019 0.029 0.045
785.429 PI 31:5 1.31 0.87 1.42 0.90 1.09 0.85 0.85 0.93 1.11 0.77 1.24 1.13 0.82 0.89 1.18 0.022 0.022 0.016
557.236 PI 14:0 1.43 0.73 1.52 0.81 1.14 0.89 0.76 1.02 1.20 0.80 1.20 1.30 0.69 0.83 1.03 0.12 0.153 0.019
543.316 PA 25:3 1.23 0.81 1.33 0.92 1.06 0.92 0.89 0.91 1.09 0.94 1.19 1.25 0.88 0.83 0.99 0.117 0.103 0.018
489.253 PA 21:2 1.40 0.79 1.31 0.94 0.93 0.86 0.94 0.90 1.24 0.90 1.13 1.13 0.86 0.79 1.04 0.099 0.046 0.024
464.323 lysoPE 18:0 1.44 0.83 1.41 0.93 1.19 0.77 0.88 0.82 1.04 0.92 1.33 1.16 0.95 0.90 0.93 0.014 0.004 0.043
558.243 PS 20:4 1.36 0.85 1.32 1.02 0.93 0.90 0.83 0.91 1.22 0.88 1.12 1.20 0.86 0.80 1.09 0.073 0.036 0.038
861.656 PG 42:0 1.39 0.84 1.22 1.00 0.89 0.89 0.93 0.90 1.26 0.98 1.03 1.16 0.92 0.80 0.99 0.138 0.185 0.026
  1. Relative intensities were measured in plasma samples of control group (n = 5), OVX group (n = 6), OVXG2 (n = 3) and OVXG5 (n = 3) using a linear mixed model. Results are fold changes (FC) of the lipid abundance between the OVXG5 and the OVX groups and between the OVXG2 and the OVXG5 groups from month one to month five, among identified compounds by LC-MS. FC with a value > 1 indicated a relatively higher intensity present in treated animals, whereas a value < 1 indicated a relatively lower intensity compared with their respective control animals
  2. All FC values, which are in bold, are significant at p < 0.05 calculated using post-hoc Fisher’s Least Significant Difference (LSD) test for pair-wise multiple comparison of the group means
  3. CL cardiolipin, CerP ceramide 1-phosphates, PI phosphatidylinositol, PA phosphatidic acid, lysoPE lysophosphatidylethanolamines, PS phosphatidylserines, PG phosphatidylglycerol