Effects of short- and long-term glucocorticoid-induced osteoporosis on plasma metabolome and lipidome of ovariectomized sheep

Table 3 Effect of OVX and OVXG on the lipidome of sheep in the short-term approach

m/z	Lipid class	OVX vs Control		OVXG vs OVX		p
		FC	FC	FC	FC	p
		1	2	1	2	Trt	Time	Int
735.521	PG 33:0	1.08	0.91	1.01	1.01	0.002	0.075	0.003
752.511	CL 76:7	1.11	1.00	1.01	0.83	0.004	0.003	0.013
726.496	CL 72:5	1.08	1.02	1.00	0.96	0.005	0.011	0.016
785.429	PI 31:5	1.15	0.98	0.99	0.87	0.011	0.01	0.028
557.236	PI 14:0	1.23	0.94	1.02	0.82	0.035	0.104	0.038

Relative intensities were measured in plasma samples of control group (n = 10), OVX group (n = 12) and OVXG (n = 6) using linear mixed models. Results are fold changes (FC) of the lipid intensities between the OVX and control groups and between the OVXG and the OVX groups at month one and month two, among identified compounds by LC-MS. FC with a value > 1 indicated a relatively higher intensity present in treated animals, whereas a value < 1 indicated a relatively lower intensity compared with their respective control animals
PG phosphatidylglycerol, CL cardiolipin, PI phosphatidylinositol

ISSN: 1471-2474