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Table 1 Effect of OVX and OVXG on the metabolite profile of sheep: short-term approach

From: Effects of short- and long-term glucocorticoid-induced osteoporosis on plasma metabolome and lipidome of ovariectomized sheep

m/z Metabolite OVX vs Control OVXG vs OVX p
FC FC FC FC
1 2 1 2 Trt Time Int
233.803 5-Methoxytryptophan 1.94 2.95 1.63 1.20 < 0.0001 < 0.0001 < 0.0001
148.039 Methionine 0.90 1.17 1.56 2.68 0.005 < 0.0001 0.028
161.903 5-Hydroxylysine 0.79 1.11 1.63 1.13 0.086 0.275 0.012
144.044 Indole-3-carboxaldehyde 0.74 1.15 2.32 1.73 0.006 0.386 0.001
116.070 L-Valine 0.75 1.05 1.75 1.27 0.015 0.096 0.007
128.034 2-Pyrrolidone-5-carboxylic acid 0.78 1.03 1.38 1.08 0.445 0.4 0.009
131.081 Glutaric acid 0.89 1.15 1.48 1.20 0.074 0.241 0.008
203.138 D-Tryptophan 0.73 0.96 1.63 1.19 0.42 < 0.0001 0.042
  1. Relative intensities were measured in plasma samples of control group (n = 10), OVX group (n = 12) and OVXG (n = 6) using linear mixed models. Results are fold changes (FC) of the lipid intensities between the OVX and control groups and between the OVXG and the OVX groups at month one and month two, among identified compounds by LC-MS. FC with a value > 1 indicated a relatively higher intensity present in treated animals, whereas a value < 1 indicated a relatively lower intensity compared with their respective control animals
  2. All FC values, which are in bold, are significant (p < 0.05)
  3. p calculated using post-hoc Fisher’s least significant difference (LSD) test for pair-wise multiple comparison of the group means