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Table 5 The results of the meta-analysis for the association between IL-6 gene polymorphisms and osteoporosis

From: Association of IL-6 174G/C (rs1800795) and 572C/G (rs1800796) polymorphisms with risk of osteoporosis: a meta-analysis

Genetic Model N Test of association Tests for heterogeneity Egger’s test
OR (95%CI) ph P value I2 P
IL-6 174G/C8
G VS C 1.09 (0.90–1.33) 0.369 0.011 61.40% 0.076
CC VS GG 0.89 (0.64–1.24) 0.48 0.092 44.80% 0.171
GC + CC VS GG 1.03 (0.83–1.28) 0.812 0.096 44.20% 0.125
CC VS GG + GC 0.81 (0.60–1.09) 0.162 0.097 42.10% 0.272
IL-6 572C/G3
C VS G 0.76 (0.56–1.04) 0.083 0.159 45.60% 0.226
GG VS CC 2.25 (1.55–3.26) 0 0.417 0.00% 0.306
CG + GG VS CC 1.42 (0.78–2.56) 0.253 0.013 77.00% 0.153
GG VS CC + CG 1.96 (1.36–2.83) 0 0.516 0.00% 0.365
  1. IL-6 174G/C: allele model: G VS C; additive model: CC VS GG; dominant model: GC + CC VS GG; recessive model: CC VS GG + GC
  2. IL-6 572C/G: allele model: C VS G; additive model: GG VS CC; dominant model: CG + GG VS CC; recessive model: GG VS CC + CG