Association of IL-6 174G/C (rs1800795) and 572C/G (rs1800796) polymorphisms with risk of osteoporosis: a meta-analysis

Table 5 The results of the meta-analysis for the association between IL-6 gene polymorphisms and osteoporosis

Genetic Model	N	Test of association		Tests for heterogeneity		Egger’s test
Genetic Model	N	OR (95%CI)	p_h	P value	I²	P
IL-6 174G/C8
G VS C		1.09 (0.90–1.33)	0.369	0.011	61.40%	0.076
CC VS GG		0.89 (0.64–1.24)	0.48	0.092	44.80%	0.171
GC + CC VS GG		1.03 (0.83–1.28)	0.812	0.096	44.20%	0.125
CC VS GG + GC		0.81 (0.60–1.09)	0.162	0.097	42.10%	0.272
IL-6 572C/G3
C VS G		0.76 (0.56–1.04)	0.083	0.159	45.60%	0.226
GG VS CC		2.25 (1.55–3.26)	0	0.417	0.00%	0.306
CG + GG VS CC		1.42 (0.78–2.56)	0.253	0.013	77.00%	0.153
GG VS CC + CG		1.96 (1.36–2.83)	0	0.516	0.00%	0.365

IL-6 174G/C: allele model: G VS C; additive model: CC VS GG; dominant model: GC + CC VS GG; recessive model: CC VS GG + GC
IL-6 572C/G: allele model: C VS G; additive model: GG VS CC; dominant model: CG + GG VS CC; recessive model: GG VS CC + CG

ISSN: 1471-2474