Skip to main content

Table 1 Scale for quality assessment of molecular association studies

From: Association of IL-6 174G/C (rs1800795) and 572C/G (rs1800796) polymorphisms with risk of osteoporosis: a meta-analysis

Criterion Score
Source of case
Selected from population 2
Selected from hospital 1
Not described 0
Source of control
Population-based 3
Blood donors or volunteers 2
Hospital-based 1
Not described 0
Ascertainment of osteoporosis
WHO 2
Diagnosis of osteoporosis by patient medical record 1
Not described 0
Ascertainment of control
Controls were tested to screen out 2
Controls were subjects who did not report osteoporosis, no objective testing 1
Not described 0
Matching
Controls matched with cases by age and sex 2
Controls matched with cases only by age or sex 1
Not matched or not described 0
Genotyping examination
Genotyping done blindly and quality control 2
Only genotyping done blindly or quality control 1
Unblinded and without quality control 0
Specimens used for determining genotypes
Blood cells or normal tissues 1
Tumor tissues or exfoliated cells of tissue 0
HWE
HWE in the control group 1
Hardy-Weinberg disequilibrium in the control group 0
Association assessment
Assess association between genotypes and osteoporosis with appropriate statistics and adjustment for confounders 2
Assess association between genotypes and osteoporosis with appropriate statistics without adjustment for confounders 1
Inappropriate statistics used 0
Total sample size
> 500 3
200–500 2
< 200 1
HWE: Hardy-Weinberg equilibrium