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Fig. 5 | BMC Musculoskeletal Disorders

Fig. 5

From: Differential proteomic analysis of fetal and geriatric lumbar nucleus pulposus: immunoinflammation and age-related intervertebral disc degeneration

Fig. 5

Complement and coagulation cascade pathways (hsa04610) and the cytokine-cytokine receptor interaction pathway (hsa04060) (geriatric/ fetal). a In the coagulation cascade pathway, coagulation factors, including FII, FXI, FXII, and FXIII, and anticoagulation factors, including AT3, HCII, and PCI, were significantly upregulated. In particular, the intrinsic coagulation pathway was activated. Regarding the complement cascade pathway, C1-C9, FB, FH, FD, and FI were significantly upregulated. Both the classic and alternative pathways of the complement cascade were activated. b In the cytokine-cytokine receptor interaction pathway, the following proteins were significantly upregulated: CXCL7, CXCL12, CXCL14, and CCL18 in the chemokine family; IL-11 in the hematopoietin family; VEGFA in the PDGF family; and LTA in the TNF family. TGFB2 and GDF5 in the TGF-β family were also upregulated, whereas TGFB3 was downregulated

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