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Table 2 Trend of IL-6 and CRP: comparisons of baseline and postoperative levels

From: Normal trajectory of Interleukin-6 and C-reactive protein in the perioperative period of total knee arthroplasty under an enhanced recovery after surgery scenario

Study parameter

Group

Mean Difference

Multiple comparisons

(Dunnett’s method) with preoperative

IL-6 (pg/mL)

Preoperative

12 h

51.18

< 0.001

48 h

53.01

< 0.001

3 days

28.95

< 0.001

2 weeks

3.30

0.943

CRP (mg/L)

Preoperative

12 h

21.82

< 0.001

48 h

63.22

< 0.001

3 days

72.63

< 0.001

2 weeks

3.32

0.816

  1. Normality test (Shapiro-Wilk test) failed; thus, Friedman’s one-way repeat-measures analysis of variance was applied, which gave p < 0.001 for both IL-6 and CRP; post hoc Dunnett’s test, which is an extension of the Friedman RM test, compared each pairwise data to find which pair differed from baseline; IL-6 interleukin-6, CRP C-reactive protein, RM repeat measure