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Fig. 3 | BMC Musculoskeletal Disorders

Fig. 3

From: In vivo fluorescence molecular tomography of induced haemarthrosis in haemophilic mice: link between bleeding characteristics and development of bone pathology

Fig. 3

Haemophilic mice develop bone pathology 14 days after induced haemarthrosis. a Pathological bone remodelling in a F8-KO mouse. a 3D volume of an induced knee of a haemophilic mouse showing pathological bone remodelling. b, c, d: sagittal, transverse and coronal sections showing periosteal bone remodelling (arrows) and osteophytosis (arrowheads) on femur (F) and tibia (T). The blue box indicates the area used for bone volume fraction analysis on tibia. b: Half (12/24) of the F8-KO mice had a positive bone remodelling score, ranging from 1 to 5 and significantly higher than sham and WT mice. c: Bone volume fraction was significantly decreased in the proximal part of tibia of the injured knee compared to the contralateral. d: In addition, cortical bone volume was significantly increased in the injured knee compared to the contralateral. Statistical significance levels are marked: *P < 0.05, **P < 0.01. Error bars represent the standard deviation

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