Table 1 Diagnostic accuracy of PJI (Periprosthetic Joint Infection) diagnosis using serum or synovial fluid biomarkers (CRP (C-reactive protein), AUC (Area under the curve), PCT (Procalcitonin) AD-1 (alpha-1-defensin))
Parameter | PJI (n = 23) | Aseptic (n = 47) | Cut-Off | Sensitivity | Specifity | p-value |
|---|---|---|---|---|---|---|
Serum CRP (mg/dl) | 2.3 (0.0–8.6) | 0.35 (0.0–1.9) | 0.5 | 57 | 81 | < 0.001 |
Synovial CRP (μg/ml) | 19.6 (0.6–339) | 1.4 (0.4–5.3) | 6.9 | 26 | 100 | < 0.001 |
Serum PCT (ng/ml) | 0.05 (0.0–1.03) | 0.02 (0.0–0.18) | 0.1 | 26 | 81 | < 0.001 |
0.3 | 17 | 84 | ||||
0.5 | 13 | 91 | ||||
Synovial PCT (ng/ml) | 2.7 (0.53–9.7) | 8.7 (0.25–87.9) | 1.0 | 87 | 0 | < 0.001 |
5.0 | 13 | 52 | ||||
Synovial AD-1 (μg/ml) | 3.6 (0.2–5.7) | 2.0 (0.2–5.7) | 4.8 | 52 | 88 | 0.006 |