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Table 1 Diagnostic accuracy of PJI (Periprosthetic Joint Infection) diagnosis using serum or synovial fluid biomarkers (CRP (C-reactive protein), AUC (Area under the curve), PCT (Procalcitonin) AD-1 (alpha-1-defensin))

From: Is Procalcitonin (PCT) a reliable biomarker for preoperative diagnosing of low grade periprosthetic joint infection? A prospective study

ParameterPJI (n = 23)Aseptic (n = 47)Cut-OffSensitivitySpecifityp-value
Serum CRP (mg/dl)2.3 (0.0–8.6)0.35 (0.0–1.9)0.55781< 0.001
Synovial CRP (μg/ml)19.6 (0.6–339)1.4 (0.4–5.3)6.926100< 0.001
Serum PCT (ng/ml)0.05 (0.0–1.03)0.02 (0.0–0.18)0.12681< 0.001
0.31784
0.51391
Synovial PCT (ng/ml)2.7 (0.53–9.7)8.7 (0.25–87.9)1.0870< 0.001
5.01352
Synovial AD-1 (μg/ml)3.6 (0.2–5.7)2.0 (0.2–5.7)4.852880.006