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Table 1 Characteristics of the included studies

From: Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: a systematic review and meta-analysis

Author,year

Study

Ethical approval

Sample Size

Gender (M/F)

Age, years

BMI(kg/m2)

Radiographic Classification (K-L)

Clinical Outcomes

Follow-up Periods

PRP + HA

PRP

HA

PRP + HA

PRP

HA

PRP + HA

PRP

HA

PRP + HA

PRP

HA

Michele Abate 2015 [17]

Co,R

Yes

40

40

–

31/9

21/

19

–

56.7±

11.2

60.9 ± 9

–

23.7 ± 2

24.1±

1.6

–

II-III

VAS,AE

6 ms

Wenxing Yu 2018 [18]

RCT

Yes

96

104

88

50/46

50/

54

48/40

46.5±

7.5

46.2 ± 8.6

51.5 ± 9.3

–

–

–

I,II,III,IV

WOMAC,

AE

12 ms

Yanqing Guo 2016 [19]

Co,P

Yes

63

63

–

18/45

12/

51

–

61.2±

9.6

60.7 ± 10.1

–

24.2 ± 4.2

24.6±

3.9

–

I,II,III

VAS,AE,

WOMAC

12 ms

Quanwei Ding 2017 [20]

RCT

Yes

20

27

–

2/18

8/

19

–

56.75±

9.536

62.11 ± 12.5

–

24.31±

3.764

24.27 ± 3.636

–

I,II,III

WOMAC,

VAS,

Lequesne scores

6 ms

Xin-liang Zhao 2018 [21]

RCT

Yes

62

62

–

35/27

37/

25

–

55.73 ± 7.18

56.32 ± 8.13

–

–

–

–

–

VAS

1 month

Yanqing Guo 2018 [22]

RCT

Yes

63

63

–

45/18

51/

12

–

61 ± 10

61 ± 10

–

24 ± 4

24 ± 4

–

I,II,III

VAS,AE

12 ms

Chenrong Ke 2016 [23]

RCT

Yes

50

50

50

25/25

24/

26

23/27

57.8 ± 6.9

59.3 ± 7.1

58.8 ± 6.4

–

–

–

I,II,III,IV

Lequesne scores,AE

12 ms

  1. Co Cohort study, P prospective study, R retrospective study, RCT randomized control trail, BMI body mass index, HA hyaluronic acid, K-L Kellgren and Lawrence grading scale, PRP platelet-rich plasma, AE Adverse events, VAS visual analog scale, WOMAC Western Ontario and McMaster Universities Arthritis Index, ms months