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Table 1 Characteristics of the included studies

From: Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: a systematic review and meta-analysis

Author,year Study Ethical approval Sample Size Gender (M/F) Age, years BMI(kg/m2) Radiographic Classification (K-L) Clinical Outcomes Follow-up Periods
PRP + HA PRP HA PRP + HA PRP HA PRP + HA PRP HA PRP + HA PRP HA
Michele Abate 2015 [17] Co,R Yes 40 40 31/9 21/
19
56.7±
11.2
60.9 ± 9 23.7 ± 2 24.1±
1.6
II-III VAS,AE 6 ms
Wenxing Yu 2018 [18] RCT Yes 96 104 88 50/46 50/
54
48/40 46.5±
7.5
46.2 ± 8.6 51.5 ± 9.3 I,II,III,IV WOMAC,
AE
12 ms
Yanqing Guo 2016 [19] Co,P Yes 63 63 18/45 12/
51
61.2±
9.6
60.7 ± 10.1 24.2 ± 4.2 24.6±
3.9
I,II,III VAS,AE,
WOMAC
12 ms
Quanwei Ding 2017 [20] RCT Yes 20 27 2/18 8/
19
56.75±
9.536
62.11 ± 12.5 24.31±
3.764
24.27 ± 3.636 I,II,III WOMAC,
VAS,
Lequesne scores
6 ms
Xin-liang Zhao 2018 [21] RCT Yes 62 62 35/27 37/
25
55.73 ± 7.18 56.32 ± 8.13 VAS 1 month
Yanqing Guo 2018 [22] RCT Yes 63 63 45/18 51/
12
61 ± 10 61 ± 10 24 ± 4 24 ± 4 I,II,III VAS,AE 12 ms
Chenrong Ke 2016 [23] RCT Yes 50 50 50 25/25 24/
26
23/27 57.8 ± 6.9 59.3 ± 7.1 58.8 ± 6.4 I,II,III,IV Lequesne scores,AE 12 ms
  1. Co Cohort study, P prospective study, R retrospective study, RCT randomized control trail, BMI body mass index, HA hyaluronic acid, K-L Kellgren and Lawrence grading scale, PRP platelet-rich plasma, AE Adverse events, VAS visual analog scale, WOMAC Western Ontario and McMaster Universities Arthritis Index, ms months