Table 1 The bacteria and the antibiotics we used
From: Antibiotic treatment regimens for bone infection after debridement: a study of 902 cases
Bacteria | Intravenous antibiotics | Oral antibiotics | ||
|---|---|---|---|---|
Adults | Pediatrics | Adults | Pediatrics | |
MSSA/MSSE | Cefazolin:2 g q8h. Cefuroxime:1.5 g q8h. Ceftriaxone:2 g q12h. Levofloxacin:600 mg qd, Moxifloxacin:400 mg qd | Cefazolin:50-100 mg/(kg.d) q8h. Cefuroxime: 30-100 mg/(kg.d) q8h. Ceftriaxone:20-80 mg/(kg.d) qd | Levofloxacin:500 mg qd, Moxifloxacin:400 mg qd) . Cefuroxime:500 mg bid | Cefuroxime: 10 mg/Kg, bid |
MRSA/MRSE | Vancomycin:15~20 mg/Kg q8~12h. Linezolid:600 mg q12h | Vancomycin:40 mg/(kg.d) 2 to 4 times/d. Linezolid: 10 mg/kg q8h | Linezolid:600 mg q12h. Fluoroquinolone. | Linezolid: 10 mg/kg q8h |
P.aeruginosa/E.coli/E.cloaca/K. pneumoniae | Ceftazidime:2 g q8h/Cefepime:2 g q12h/PiperacillinTazobactam:4.5 g q8h /Levofloxacin;500 mg qd/Amikacin:15 mg/Kg qd (usually used in combination) | Ceftazidime:30-100 mg/(kg.d) q8h. Cefepime:40 mg/Kg q12h. PiperacillinTazobactam:112.5 mg/Kg q8h | Levofloxacin: 500 mg qd | No oral |
Others | According to drug sensitivity | According to drug sensitivity | According to drug sensitivity | According to drug sensitivity |
Negative | Ceftazidime / Cefepime / Fluoroquinolone | Ceftriaxone 20-80 mg/(kg.d) qd | Fluoroquinolone | Cefuroxime: 10 mg/Kg, bid |