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Table 6 Results From 3 Studies Investigating Other Gut-Related Markers

From: Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review

Author (Year) Cohort Material / Biomarker Results p-value for diff
FMS Controls
Pimentel (2004) [17] 42 FMSa
111 IBS
15 HC
Breath(SIBO) 100% IBS 84%
HC 20%
< 0.05
< 0.0001
Michalsen (2005) [18] 21 FMS9 RA StoolpH & sIgAfollowing fasting   No differences between FMS vs RA groups or with different interventions n.s.
14 FMS7 RA StoolpH & sIgAfollowing MedDiet    n.s.
Goebel (2008) [19] 40 FMS
17 CRPS
57 HC
UrineGD permeabilitySI permeability 32.5%37.5% CRPS 35.3%, HC 5%CRPS 17.6%, HC 0% < 0.0001b < 0.0002&
  1. Key: a = 22 (54%) had IBS; b = p-value compared to controls; FMS Fibromyalgia; CRPS chronic regional pain syndrome; HC healthy controls; GD gastroduodenal; SI small intestine; IBS irritable bowel syndrome; RA rheumatoid arthritis; MedDiet Mediterranean Diet; SIBO small intestinal bacterial overgrowth; n.s. not significant.