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Table 5 Results from 3 studies (4 papers) Investigating Metabolites and Metabolomics

From: Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review

Author (Year) Subjects
Controls
Material
Biomarker
FMS Subjects P value for diff
Malatji (2017) [24] 18 FMS11 FC10 MC41 YC UrineNMR metabolome Compared to YC
↑ hippuric acid
↑ succinic acid
↑ lactic acid ↑ 2-Hydroxyisobutyric acid
p = 0.0966(ns)
p = 0.0001 (MW)
p = 0.0044
p = 0.0001
Malatji (2019) [25] 17 FMS11 FC10 MC41 YC UrineGC-MS metabolome ↑ 14 metabolites c.f. MC↑ 4-hydroxyisobutyric acid c.f. MC & YC
↑ arabinose c.f. MC
All < 0.001
(MW & BF)
p = 0.00109
Minerbi (2019) [27] 77 FMS11 FC20 HM48 UC Serum
Metabolites
Compared to UC:
↑serum butyrate ↓serum propionic acid
↓isobutyric acid
p = 0.005p = 0.006
p = 0.056 (ns)
Clos-Garcia (2019) [26] 105 FMS54 HC Serum
Metabolome
↓ gadC, glnA, glsA2, gadB1, gadB2↑ lysine, ornithine
↑threonine, homoserine, glutamine, and argininea
p < 0.05
p < 0.05
p < 0.001
  1. Key: FMS Fibromyalgia; NMR nuclear magnetic resonance spectrometry; GC-MS gas chromatography–mass spectrometry: HC healthy controls; FC family controls; MC matched controls; YC young controls; HM household members; UC unrelated controls; c.f. compared to; MW Mann Whitney test; BF Bonferroni-Holm test; ns not significant; gad glutamate decarboxylase; gln glutamine synthetase; gls glutaminase: a all identified as likely of bacterial origin.