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Table 4 Results from 4 studies Investigating Gastrointestinal Microbiota Taxa and Antibodies

From: Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review

Author (Year) Patients
Material & Procedure Results p-value Other
Michalsen (2005) [18] 21 FMS
9 RA
No differences n.s pre- vs post-fasting
14 FMS
7 RA
No differences n.s pre- vs post-MedDiet
Goebel (2008) [19] 33 FMS17 CRPS 57 HC Serum antibodies
FMS 27% positive
CRPS 13%
HC Not tested
NR Trend for seropositivity assoc. with IP (Table 4)
Minerbi (2019) [27] 77 FMS
11 FC
20 HM
48 UC
16S rRNA gene
(V5-V6 region) / metagenome
↓ Faecalibacterium and Bacteroides, ↑ Intestinimonas, Flavonifractor, Butyricoccus Eisenbergiella and Enterobacter. < 0.01 Non-significant differences in sample diversity
Variance FMS vs UC
Clos-Garcia (2019) [26] 105 FMS
54 HC
16S rDNA microbiome(V3–V4 region)
FMS: Absent families: Bifidobacteriaceae and Bacteroidales↑ Dorea, Roseburia, Alistipes, Papillibacter, Subdoligranulum↓ Bacteroides, Bifidobacterium, Eubacterium, Clostridium All p ≤ 0.05 Controls had higher diversity
  1. Key: n.s. not statistically significant; NR not reported; FMS Fibromyalgia; RA rheumatoid arthritis; HC healthy controls; CRPS chronic regional pain syndrome; IP intestinal permeability; FC family controls; HM household members; UC unrelated controls.