CHD7 gene polymorphisms in female patients with idiopathic scoliosis

Table 8 Alleles and genotypes distribution between patients with different age of onset IS

Allele/genotype	AIS N = 152	EOIS N = 59	Independentmodel P-value	P-value	OR (CI 0.95)
rs1017861
G	84.9	89		0.35^a	0.69 (0.36–1.34)
A	15.1	11		0.35^a	0.69 (0.36–1.34)
GG	71.1	79.7	0.44	0.99^b	0.86 (0.09–8.41)
GA	27	18.6
AA	2	1.7		0.27^c	0.63 (0.30–1.29)
rs4738824
G	78	83.1		0.30^a	0.72 (0.42–1.25)
A	22	16.9		0.30^a	0.72 (0.42–1.25)
GG	57.9	69.5	0.27	0.99^b	1.29 (0.12–14.54)
GA	40.8	28.8
AA	1.3	1.7		0.16^c	0.60 (0.32–1.15)
rs4738813
T	66.8	74.6		0.15^a	1.46 (0.91–2.07)
C	33.2	25.4		0.15^a	1.46 (0.91–2.07)
TT	48.7	54.2	0.58	0.45^b	0.58 (0.19–1.79)
CT	40.1	39
CC	11.2	6.8		0.57^c	0.80 (0.44–1.46)

Abbreviations: IS idiopathic scoliosis, OR odds ratio, CI 95% confidence interval, P-value for: ^a – alleles, ^b – dominant model, ^c – recessive model

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