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Table 2 Allele and genotype frequency (%) in patients with IS and healthy controls

From: CHD7 gene polymorphisms in female patients with idiopathic scoliosis

Allele/genotype

Patients N = 211

Controls N = 83

Independent model P-value

P-value

OR (95% CI)

rs1017861

G

87.7

74.6

 

0.0001a

2.4 (1.5–3.8)

A

12.3

25.4

GG

77.2

55.4

0.0006

0.06b

3.3 (0.9–12.7)

GA

28

38.6

  

AA

1.9

6.0

0.002c

0.4 (0.2–0.6)

rs4738824

G

81.8

79.5

 

0.53a

0.84 (0.6–1.2)

A

18.3

20.5

GG

65.9

63.9

0.54

0.47b

2.1 (0.6–7.9)

GA

31.7

32.1

  

AA

2.4

4.8

0.84 c

0.9 (0.5–1.6)

rs4738813

T

68.7

69.3

 

0.97a

0.97 (0.66–1.44)

C

31.2

30.7

TT

48.2

49.4

0.98

0.99b

0.99 (0.44–2.25)

CT

41

39.8

  

CC

10.8

10.8

0.97c

0.96 (0.58–1.59)

  1. Abbreviations: IS idiopathic scoliosis, OR odds ratio, CI 95% confidence interval, P-value for: a – alleles, b – dominant model, c – recessive model
  2. significant P-values (<0.05) are in bold