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Fig. 4 | BMC Musculoskeletal Disorders

Fig. 4

From: LncRNA MCM3AP-AS1 regulates miR-142-3p/HMGB1 to promote LPS-induced chondrocyte apoptosis

Fig. 4

MCM3AP-AS1 over-expression led to up-regulated HMGB1. HMGB1 is a direct downstream target of miR-142-3p. The effects of MCM3AP-AS1 and miR-142-3p over-expression on HMGB1 expression at mRNA and protein levels were analyzed by qPCR (a) and western blot (b), respectively. Gene names on X-axis indicated the over-expression of this gene. C on X-axis, control cells, cells without transfection, NC on X-axis, negative control, cells transfected with empty vector or NC miRNA. Experiments were repeated 3 times and data were expressed as mean values. *, p < 0.05

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