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Table 3 Musculoskeletal Infection Society (MSIS) criteria proposed in 2011

From: Diagnostic criteria of periprosthetic joint infection: a prospective study protocol to validate the feasibility of the 2018 new definition for Chinese patients

Major criteria

 1. There is a sinus tract communicating with the prosthesis

 2. A pathogen is isolated by culture from at least two separate tissue or fluid samples obtained from the affected prosthetic joint

Minor criteria

 1. Elevated serum erythrocyte sedimentation rate (ESR) and serum C-reactive protein (CRP) concentration

 2. Elevated synovial leukocyte count

 3. Elevated synovial neutrophil percentage (PMN%)

 4. Presence of purulence in the affected joint

 5. Isolation of a microorganism in one culture of periprosthetic tissue or fluid

 6. Greater than five neutrophils per high-power field in five high-power fields observed from histologic analysis of periprosthetic tissue at× 400 magnification.

  1. PJI exists when one of the major criteria occurs or four of the six minor criteria occur
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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