Fig. 5From: Increased lactic acid content associated with extracellular matrix depletion in a porcine disc degeneration induced by superficial annular lesionIncreased lactic acid and nerve growth factor (NGF) content and extracellular matrix depletion of the intervertebral disc was found in annular lesion (AL) group. a-b The content of lactic acid in the nucleus pulposus of L1–2 intervertebral disc was dramatically increased over time in AL group compared with sham group at 4/8/12 weeks after surgery. c-d The gene expression and content of aggrecan in the nucleus pulposus of L1–2 intervertebral disc was decreased over time in AL group compared with sham group at 4/8/12 weeks after surgery. e-f The gene expression and content of aggrecan in the nucleus pulposus of L1–2 intervertebral disc was decreased over time in AL group compared with sham group at 4/8/12 weeks after surgery. ** p < 0.01; *** p < 0.001 compared with the sham group at same time pointBack to article page