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Fig. 5 | BMC Musculoskeletal Disorders

Fig. 5

From: Increased lactic acid content associated with extracellular matrix depletion in a porcine disc degeneration induced by superficial annular lesion

Fig. 5

Increased lactic acid and nerve growth factor (NGF) content and extracellular matrix depletion of the intervertebral disc was found in annular lesion (AL) group. a-b The content of lactic acid in the nucleus pulposus of L1–2 intervertebral disc was dramatically increased over time in AL group compared with sham group at 4/8/12 weeks after surgery. c-d The gene expression and content of aggrecan in the nucleus pulposus of L1–2 intervertebral disc was decreased over time in AL group compared with sham group at 4/8/12 weeks after surgery. e-f The gene expression and content of aggrecan in the nucleus pulposus of L1–2 intervertebral disc was decreased over time in AL group compared with sham group at 4/8/12 weeks after surgery. ** p < 0.01; *** p < 0.001 compared with the sham group at same time point

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