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Fig. 4 | BMC Musculoskeletal Disorders

Fig. 4

From: Increased lactic acid content associated with extracellular matrix depletion in a porcine disc degeneration induced by superficial annular lesion

Fig. 4

Expression of type II collagen (Col-II) significantly decreased in NP tissue of AL group. a Immunohistochemical staining showed the positive area of Col-II in the NP tissue decreased with the degree of degeneration. b Statistical analysis of the average optical density of type II collagen immunohistochemical staining, ** p < 0.01; *** p < 0.001 compared with the sham group at same time point. c Western blot showed that the expression of type I collagen (Col-I) was increased, and Col-II decreased in NP tissue of degeneration group 12 weeks after surgery. d Statistical analysis of the western blot bands, ** p < 0.01 compared with the sham group at same time point. e-f The gene expression of matrix metallopeptidase 3 and 13 (MMP3 and MMP13) gradually increased over time in AL group compared with sham group at 4/8/12 weeks after surgery

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