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Table 2 Primary and secondary outcomes regarding laboratory values and clinical outcomes after surgery

From: Intravenous and subsequent long-term oral tranexamic acid in enhanced-recovery primary total knee arthroplasty without the application of a tourniquet: a randomized placebo-controlled trial

Variable

Group A

Group B

P value

Primary outcomes

 Total blood loss (mL)b

671.7 ± 352.7

915.8 ± 243.4

0.001

Secondary outcomes

  Postoperative transfusion

 Patients requiring transfusion

2 (3.33%)

2 (3.45%)

0.44

 Units transfused (IU)

3.5

4

NA

 Postop. laboratory values

 Hemoglobin (g/L)b

POD 1

115.3 ± 13.9

117.1 ± 11.6

0.55

POD 3

106.0 ± 10.9

99.7 ± 8.4

0.001

POD 14

123.8 ± 10.3

121.3 ± 8.1

0.13

 Hematocrit (%)b

POD 1

35.1 ± 4.2

35.7 ± 3.2

0.43

POD 3

32.3 ± 2.9

30.0 ± 2.5

0.001

POD 14

37.0 ± 4.5

36.4 ± 4.6

0.45

 FDP (mg/L)b

POD 1

13.7 ± 7.8

24.9 ± 11.3

0.001

POD 3

6.9 ± 3.4

12.0 ± 10.0

0.001

POD 14

4.4 ± 2.5

5.2 ± 2.4

0.083

 D-Dimer (mg/L)b

POD 1

4.6 ± 2.2

8.4 ± 8.0

0.001

POD 3

1.5 ± 1.1

3.3 ± 2.1

0.001

POD 14

1.2 ± 0.9

1.3 ± 0.5

0.22

Postop. knee function

 ROM (°)b

POD 1

99.7 ± 11.8

100.1 ± 11.7

0.58

POD 3

108.1 ± 4.9

107.4 ± 5.2

0.44

POD 14

110.9 ± 8.9

108.2 ± 9.4

0.11

PO 3 M

114.0 ± 7.0

113.7 ± 9.5

0.82

 KSS clinical scoreb

POD 3

48.2 ± 8.9

45.6 ± 8.5

0.32

POD 14

77.3 ± 6.4

75.2 ± 9.1

0.15

PO 3 M

82.8 ± 5.5

82.5 ± 4.3

0.73

 KSS function scoreb

POD 3

44.5 ± 10.6

43.1 ± 10.2

0.27

POD 14

68.6 ± 8.1

69.5 ± 8.4

0.53

PO 3 M

75.5 ± 5.6

76.7 ± 5.3

0.25

 Knee circumference (cm)b

POD 1

42.0 ± 3.7

43.8 ± 3.3

0.06

POD 3

43.1 ± 1.9

46.1 ± 3.7

0.001

POD 14

41.4 ± 2.9

44.9 ± 2.2

0.001

PO 3 M

41.1 ± 3.2

41.6 ± 3.0

0.28

 VAS pain scoreb

POD 1

3.8 ± 1.5

4.2 ± 2.0

0.26

POD 3

2.7 ± 0.8

2.9 ± 0.7

0.11

POD 14

2.2 ± 1.0

2.0 ± 0.8

0.32

PO 3 M

0.7 ± 0.9

0.6 ± 0.8

0.35

 Hospital stay (day)b

3.7 ± 1.2

4.0 ± 0.9

0.15