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Table 5 ROC curves comparing the ccf n-DNA and mt-DNA to discriminate controls and Lenke 1 or Lenke 5 AIS patients

From: Changes in circulating cell-free nuclear DNA and mitochondrial DNA of patients with adolescent idiopathic scoliosis

Test Cutoff (GE/ml) AUC (95% CI) Sensitivity Specificity P value
Lenke 1 n-DNA-GAPDH 729 0.586 (0.438–0.733) 0.667 0.550 0.274
n-DNA-ACTB 6940 0.675 (0.532–0.818) 0.619 0.750 0.026
mt-DNA 4,089,116 0.619 (0.477–0.762) 0.450 0.810 0.129
Lenke 5 n-DNA-GAPDH 732 0.629 (0.465–0.793) 0.625 0.667 0.139
n-DNA-ACTB 6953 0.637 (0.473–0.801) 0.667 0.619 0.116
mt-DNA 164,261,352 0.554 (0.376–0.731) 0.375 1.000 0.539
  1. Abbreviation: ccf cell free circulating, AUC area under curves