BMC Musculoskeletal Disorders

Table 5 ROC curves comparing the ccf n-DNA and mt-DNA to discriminate controls and Lenke 1 or Lenke 5 AIS patients

From: Changes in circulating cell-free nuclear DNA and mitochondrial DNA of patients with adolescent idiopathic scoliosis

Test		Cutoff (GE/ml)	AUC (95% CI)	Sensitivity	Specificity	P value
Lenke 1	n-DNA-GAPDH	729	0.586 (0.438–0.733)	0.667	0.550	0.274
	n-DNA-ACTB	6940	0.675 (0.532–0.818)	0.619	0.750	0.026
	mt-DNA	4,089,116	0.619 (0.477–0.762)	0.450	0.810	0.129
Lenke 5	n-DNA-GAPDH	732	0.629 (0.465–0.793)	0.625	0.667	0.139
	n-DNA-ACTB	6953	0.637 (0.473–0.801)	0.667	0.619	0.116
	mt-DNA	164,261,352	0.554 (0.376–0.731)	0.375	1.000	0.539

Abbreviation: ccf cell free circulating, AUC area under curves

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ISSN: 1471-2474

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