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Table 4 ROC curves comparing the ccf n-DNA and mt-DNA to discriminate AIS patients and controls by gender

From: Changes in circulating cell-free nuclear DNA and mitochondrial DNA of patients with adolescent idiopathic scoliosis

Test

Cutoff (GE/ml)

AUC (95% CI)

Sensitivity

Specificity

P value

Male

n-DNA-GAPDH

3170

0.667 (0.384–0.950)

0.706

0.667

0.234

n-DNA-ACTB

6940

0.725 (0.503–0.948)

0.588

0.833

0.107

mt-DNA

2,178,401

0.686 (0.443–0.930)

0.588

0.833

0.183

Female

n-DNA-GAPDH

732

0.567 (0.417–0.716)

0.635

0.600

0.434

n-DNA-ACTB

7291

0.636 (0.476–0.796)

0.769

0.533

0.111

mt-DNA

1,684,972

0.519 (0.379–0.660)

0.269

0.933

0.821

  1. Abbreviation: ccf cell free circulating, AUC area under curves