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Table 4 ROC curves comparing the ccf n-DNA and mt-DNA to discriminate AIS patients and controls by gender

From: Changes in circulating cell-free nuclear DNA and mitochondrial DNA of patients with adolescent idiopathic scoliosis

Test Cutoff (GE/ml) AUC (95% CI) Sensitivity Specificity P value
Male n-DNA-GAPDH 3170 0.667 (0.384–0.950) 0.706 0.667 0.234
n-DNA-ACTB 6940 0.725 (0.503–0.948) 0.588 0.833 0.107
mt-DNA 2,178,401 0.686 (0.443–0.930) 0.588 0.833 0.183
Female n-DNA-GAPDH 732 0.567 (0.417–0.716) 0.635 0.600 0.434
n-DNA-ACTB 7291 0.636 (0.476–0.796) 0.769 0.533 0.111
mt-DNA 1,684,972 0.519 (0.379–0.660) 0.269 0.933 0.821
  1. Abbreviation: ccf cell free circulating, AUC area under curves