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Table 1 Micro-CT analysis of femora trabecular parameters of proximal femur in three groups at different timepoint after operation

From: Bone microarchitectural parameters can detect oxytocin induced changes prior to bone density on mitigating bone deterioration in rabbit osteoporosis model using micro-CT

Time pointBMD (mg/cm2)SMI
controlOVX-vehicle groupOVX-oxytocin groupcontrolOVX-vehicle groupOVX-oxytocin group
 baseline102.73 [89.98,115.4898.57 [83.58,113.56]97.58 [81.33,113.83]0.67 [0.55,0.79]0.69 [0.46,0.92]0.67 [0.52,0.82]
  4thw91.52 [78.67,104.37]93.68 [84.94,102.42]95.75 [82.47,109.03]0.70 [0.50,0.90]0.97 [0.80,1.14]0.71 [0.59,0.83]
  8thw82.05 [68.83,95.27]57.18 [41.36,73.00]*74.66 [60.09,89.23]#0.75 [0.58,0.92]1.17 [0.97,1.37]*0.75 [0.47,1.03]#
  10thw65.24 [56.68,73.80]35.32 [27.18,43.46]*58.65 [42.10,75.20]#0.78 [0.58,0.98]1.27 [1.01,1.53]*0.79 [0.64,0.94]#
  12thw59.11 [46.76,71.46]24.47 [8.71,40.23]*50.58 [40.95,60.21]*#0.79 [0.65,0.93]1.45 [1.33,1.57]*0.86 [0.72,1.00]*#
Time pointBV/TV (%)Tb.N (mm−1)
controlOVX-vehicle groupOVX-oxytocin groupcontrolOVX-vehicle groupOVX-oxytocin group
 baseline41.25 [39.57,42.93]40.14 [38.13,42.15]41.36 [38.86,43.86]2.71 [2.39,3.03]2.68 [2.42,2.94]2.71 [2.59,2.83]
  4thw38.70 [35.95,41.45]36.63 [34.32,38.94]38.28 [37.34,39.22]2.64 [2.39,2.89]2.34 [2.15,2.53]2.58 [2.34,2.82]
  8thw38.05 [34.96,41.14]33.69 [31.21,36.17]*37.48 [36.24,38.72]#2.61 [2.50,2.72]2.29 [2.14,2.44]*2.52 [2.20,2.84]#
  10thw37.54 [35.97,39.11]28.57 [27.37,29.77]*36.91 [34.85,38.97]#2.53 [2.25,2.81]2.24 [2.09,2.39]*2.47 [2.29,2.65]#
  12thw36.51 [35.27,37.75]27.44 [25.11,29.77]*33.58 [31.93,35.23]*#2.49 [2.33,2.65]2.06 [1.84,2.28]*2.30 [2.08,2.52]*#
Time pointTb.Th (μm)Tb.Sp (μm)
controlOVX-vehicle groupOVX-oxytocin groupcontrolOVX-vehicle groupOVX-oxytocin group
 baseline171.56 [164.59,178.53]169.24 [160.43,178.05]172.34 [162.10,182.58]203.75 [194.08,213.42]204.17 [194.92,213.42]203.41 [194.67,212.15]
  4thw167.80 [156.60,179.04]163.02 [148.52,177.52]168.36 [156.19,180.53]205.20 [200.02,210.38]228.34 [217.69,238.99]207.11 [197.16,217.06]
  8thw165.24 [154.40,176.08]156.68 [145.48,167.88]162.08 [153.84,170.32]208.36 [200.62,216.10]256.14 [247.94,264.34]*217.04 [209.82,224.26]#
  10thw162.47 [151.24,173.70]136.54 [127.40,145.68]*159.87 [151.99,167.75]#209.89 [201.75,218.03]279.34 [263.87,294.81]*230.53 [222.76,238.30]#
  12thw163.40 [150.86,175.94]133.28 [124.61,141.95]*152.20 [141.87,162.53]*#216.47 [207.19,225.75]319.08 [307.94,330.22]*259.66 [251.43,267.89]*#
  1. BMD Bone mineral density, BV/TV Bone volume fraction, SMI Structure model index, Tb.N Trabecular plate number, Tb.Th Trabecular thickness, Tb.Sp Trabecular spacing, *P < 0.05 comparison with the control group at different time points; #P < 0.05 comparison with OP group at different time points; P>0.05 comparison with base point (0 week) at different time points