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Table 1 Micro-CT analysis of femora trabecular parameters of proximal femur in three groups at different timepoint after operation

From: Bone microarchitectural parameters can detect oxytocin induced changes prior to bone density on mitigating bone deterioration in rabbit osteoporosis model using micro-CT

Time point

BMD (mg/cm2)

SMI

control

OVX-vehicle group

OVX-oxytocin group

control

OVX-vehicle group

OVX-oxytocin group

 baseline

102.73 [89.98,115.48

98.57 [83.58,113.56]

97.58 [81.33,113.83]

0.67 [0.55,0.79]

0.69 [0.46,0.92]

0.67 [0.52,0.82]

  4thw

91.52 [78.67,104.37]

93.68 [84.94,102.42]

95.75 [82.47,109.03]

0.70 [0.50,0.90]

0.97 [0.80,1.14]

0.71 [0.59,0.83]

  8thw

82.05 [68.83,95.27]

57.18 [41.36,73.00]*

74.66 [60.09,89.23]#

0.75 [0.58,0.92]

1.17 [0.97,1.37]*

0.75 [0.47,1.03]#

  10thw

65.24 [56.68,73.80]

35.32 [27.18,43.46]*

58.65 [42.10,75.20]#

0.78 [0.58,0.98]

1.27 [1.01,1.53]*

0.79 [0.64,0.94]#

  12thw

59.11 [46.76,71.46]

24.47 [8.71,40.23]*

50.58 [40.95,60.21]*#

0.79 [0.65,0.93]

1.45 [1.33,1.57]*

0.86 [0.72,1.00]*#

Time point

BV/TV (%)

Tb.N (mm−1)

control

OVX-vehicle group

OVX-oxytocin group

control

OVX-vehicle group

OVX-oxytocin group

 baseline

41.25 [39.57,42.93]

40.14 [38.13,42.15]

41.36 [38.86,43.86]

2.71 [2.39,3.03]

2.68 [2.42,2.94]

2.71 [2.59,2.83]

  4thw

38.70 [35.95,41.45]

36.63 [34.32,38.94]

38.28 [37.34,39.22]

2.64 [2.39,2.89]

2.34 [2.15,2.53]

2.58 [2.34,2.82]

  8thw

38.05 [34.96,41.14]

33.69 [31.21,36.17]*

37.48 [36.24,38.72]#

2.61 [2.50,2.72]

2.29 [2.14,2.44]*

2.52 [2.20,2.84]#

  10thw

37.54 [35.97,39.11]

28.57 [27.37,29.77]*

36.91 [34.85,38.97]#

2.53 [2.25,2.81]

2.24 [2.09,2.39]*

2.47 [2.29,2.65]#

  12thw

36.51 [35.27,37.75]

27.44 [25.11,29.77]*

33.58 [31.93,35.23]*#

2.49 [2.33,2.65]

2.06 [1.84,2.28]*

2.30 [2.08,2.52]*#

Time point

Tb.Th (μm)

Tb.Sp (μm)

control

OVX-vehicle group

OVX-oxytocin group

control

OVX-vehicle group

OVX-oxytocin group

 baseline

171.56 [164.59,178.53]

169.24 [160.43,178.05]

172.34 [162.10,182.58]

203.75 [194.08,213.42]

204.17 [194.92,213.42]

203.41 [194.67,212.15]

  4thw

167.80 [156.60,179.04]

163.02 [148.52,177.52]

168.36 [156.19,180.53]

205.20 [200.02,210.38]

228.34 [217.69,238.99]

207.11 [197.16,217.06]

  8thw

165.24 [154.40,176.08]

156.68 [145.48,167.88]

162.08 [153.84,170.32]

208.36 [200.62,216.10]

256.14 [247.94,264.34]*

217.04 [209.82,224.26]#

  10thw

162.47 [151.24,173.70]

136.54 [127.40,145.68]*

159.87 [151.99,167.75]#

209.89 [201.75,218.03]

279.34 [263.87,294.81]*

230.53 [222.76,238.30]#

  12thw

163.40 [150.86,175.94]

133.28 [124.61,141.95]*

152.20 [141.87,162.53]*#

216.47 [207.19,225.75]

319.08 [307.94,330.22]*

259.66 [251.43,267.89]*#

  1. BMD Bone mineral density, BV/TV Bone volume fraction, SMI Structure model index, Tb.N Trabecular plate number, Tb.Th Trabecular thickness, Tb.Sp Trabecular spacing, *P < 0.05 comparison with the control group at different time points; #P < 0.05 comparison with OP group at different time points; P>0.05 comparison with base point (0 week) at different time points